Associations between STR autosomal markers and longevity

Age
N G BediagaM M de Pancorbo

Abstract

Life span is a complex and multifactorial trait, which is shaped by genetic, epigenetic, environmental, and stochastic factors. The possibility that highly hypervariable short tandem repeats (STRs) associated with longevity has been largely explored by comparing the genotypic pools of long lived and younger individuals, but results so far have been contradictory. In view of these contradictory findings, the present study aims to investigate whether HUMTHO1 and HUMCSF1PO STRs, previously associated with longevity, exert a role as a modulator of life expectancy, as well as to assess the extent to which other autosomal STR markers are associated with human longevity in population from northern Spain. To that end, 21 autosomal microsatellite markers have been studied in 304 nonagenarian individuals (more than 90 years old) and 516 younger controls of European descent. Our results do not confirm the association found in previous studies between longevity and THO1 and CSF1PO loci. However, significant association between longevity and autosomal STR markers D12S391, D22S1045, and DS441 was observed. Even more, when we compared allelic frequency distribution of the 21 STR markers between cases and controls, we found that 6 out of the 2...Continue Reading

References

Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Nov 1, 1993·Journal of Gerontology·M McGueB Harvald
Jan 15, 1999·European Journal of Human Genetics : EJHG·G De BenedictisC Franceschi
Nov 16, 2001·Biogerontology·A Macieira-Coelho
Jan 17, 2002·Forensic Science International : Synergy·S Hering, E Müller
Feb 8, 2006·Human Genetics·Jacob vB HjelmborgKaare Christensen
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Constanze Bonifer, David A Hume
May 15, 2008·BMC Genetics·Idan MenasheBingshu E Chen
Sep 3, 2010·Annual Review of Genetics·Rita GemayelKevin J Verstrepen
Dec 1, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P E SlagboomR G J Westendorp
Mar 17, 2011·European Journal of Human Genetics : EJHG·Nicole von Wurmb-SchwarkAlmut Nebel
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Aug 9, 2013·Human Genetics·Angela R Brooks-Wilson
Dec 10, 2013·Forensic Science International. Genetics·Jose María AznarMarian M de Pancorbo
Sep 10, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda BroerJoanne M Murabito
Mar 12, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ryan L MinsterAnne B Newman

❮ Previous
Next ❯

Citations

Dec 22, 2016·Reports on Progress in Physics·T Gershon, V V Gligorov
Aug 28, 2020·Frontiers in Genetics·Nicole WynerDennis McNevin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.