Associations between substance use disorders and major depression in parents and late adolescent-emerging adult offspring: an adoption study.

Addiction
N R MarmorsteinM McGue

Abstract

To examine whether major depressive disorder (MDD) and substance use disorders [SUDs: specifically, nicotine dependence (ND), alcohol use disorders (AUDs), and cannabis use disorders (CUDs)] in parents predicted increased risk for these disorders in late adolescent-emerging adult offspring and, specifically, the extent to which the pattern of risk differed for adopted and non-adopted youth. Late adolescent and emerging adult participants from the Sibling Interaction and Behavior Study (mean age = 18.8), a community-based investigation of adopted and non-adopted adolescents, and their parents (adoptive parents of adopted youth, biological parents of non-adopted adolescents) were included. Structured interviews were used to assess these disorders. (i) When the same disorder in parents and adolescents was examined, parental MDD was associated with increased risk for MDD among both adopted (P < 0.001) and non-adopted (P < 0.01) adolescents; in contrast, SUDs were associated with increased risk for the same SUD in non-adopted offspring (all P < 0.01). (ii) When cross-SUD effects were examined, for the most part, each SUD was associated with increased risk for other SUDs among non-adopted but not adopted offspring (most P < 0.05). (i...Continue Reading

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May 13, 2014·Clinical Child and Family Psychology Review·Misaki N NatsuakiLeslie D Leve
Jul 28, 2015·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Alicia TannerGraham Martin
Jan 21, 2014·Addiction·Arpana Agrawal, Michael T Lynskey
Sep 18, 2015·American Journal of Public Health·Denise B KandelMei-Chen Hu
May 4, 2017·Behavior Genetics·M SmolkinaM T Lynskey

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