Associations between Type 2 Diabetes Mellitus and Arterial Stiffness: A Prospective Analysis Based on the Maine-Syracuse Study

Pulse
Merrill F EliasWalter P Abhayaratna

Abstract

The aim of this study was to investigate prospective associations between type 2 diabetes mellitus status and the gold standard non-invasive method for ascertaining arterial stiffness, carotid femoral pulse wave velocity. The prospective analysis employed 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study. Pulse wave velocity at wave 7 (2006-2010) was compared between those with type 2 diabetes mellitus at wave 6 (2001-2006) (n = 52) and non-diabetics at wave 6 (n = 456), with adjustment for demographic factors, cardiovascular risk factors and lifestyle- and pulse wave velocity-related factors. Type 2 diabetes mellitus status was associated with a significantly higher pulse wave velocity (12.5 ± 0.36 vs. 10.4 ± 0.12 m/s). Multivariate adjustment for other cardiovascular risk factors and lifestyle- and pulse wave velocity-related variables did not attenuate the findings. The risk of an elevated pulse wave velocity (≥12 m/s) was over 9 times higher for those with uncontrolled type 2 diabetes mellitus than for those without diabetes (OR 9.14, 95% CI 3.23-25.9, p < 0.001). Type 2 diabetes mellitus, particularly if uncontrolled, is significantly associated with risk of arter...Continue Reading

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Citations

Oct 31, 2020·The Journal of Clinical Hypertension·Charalampos LoutradisPantelis Sarafidis
Mar 5, 2020·Journal of the American College of Cardiology·Yao LuQingbo Xu
Feb 25, 2021·Clinics·Clara Italiano MonteiroRenata Gonçalves Mendes
Oct 17, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Maria SchoinaPantelis Sarafidis
Mar 28, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Murat GulNamik Ozkan
Aug 1, 2021·BMC Cardiovascular Disorders·Dyah Samti MayasariHariadi Hariawan

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