Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population.

Environment International
Linling YuWeihong Chen

Abstract

Phthalates have been largely used for years in varieties of products worldwide. However, research on the joint toxic effect of various phthalates exposure on the liver is lacking. We aimed to assess exposure to phthalates on liver function tests (LFTs). This analysis included data on 6046 adults (≥20 years old) who participated in a National Health and Nutrition Examination Survey (NHANES) in 2007-2016. We employed linear regression and Bayesian kernel machine regression (BKMR), to explore the associations of urinary phthalate metabolites with 8 indicators of LFTs. Di(2-ethylhexyl) phthalate (ΣDEHP) was found to be positively associated with serum alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) (all P FDR < 0.05). We found significant positive associations of ∑DEHP, mono-ethyl phthalate (MEP) and mono-(carboxyisononyl) phthalate (MCNP) with total bilirubin (TBIL) (all P FDR < 0.05). ΣDEHP, mono-n-butyl phthalate (MBP), mono-(3-carboxypropyl) phthalate (MCPP) and mono-benzyl phthalate (MBzP) were negatively associated with serum ALB (all P FDR < 0.05). The BKMR analyses showed a significantly positive overall effect on ALT, AST, ALP and TBIL levels with high concentrations of phtha...Continue Reading

References

Jul 2, 1999·Regulatory Toxicology and Pharmacology : RTP·J DoullM van Gemert
Aug 18, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Moses T BilityJeffrey M Peters
Dec 14, 2004·Toxicology·Paula J LapinskasJ Christopher Corton
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Helena NyblomRolf Olsson
Sep 7, 2006·Critical Reviews in Toxicology·Ivan RusynMichael L Cunningham
Sep 5, 2008·PPAR Research·Yuki Ito, Tamie Nakajima
Feb 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rita Garcia-MartinezRajiv Jalan
Mar 7, 2013·Environmental Health Perspectives·Arnold SchecterLinda S Birnbaum
Nov 26, 2013·The Medical Clinics of North America·Tinsay A Woreta, Saleh A Alqahtani
Mar 3, 2015·Environmental Science & Technology·Sopheak NetBaghdad Ouddane
Mar 27, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Mercedes Robles-DiazUNKNOWN Faster Evidence-based Translation (SAFE-T) Consortium
May 30, 2015·Environmental Health Perspectives·K U AlwisBenjamin C Blount
Aug 16, 2016·Trends in Molecular Medicine·Silvia GazzinClaudio Tiribelli
Sep 6, 2017·The American Journal of Gastroenterology·Patompong UngprasertEric L Matteson
Nov 3, 2017·Journal of Pediatric Gastroenterology and Nutrition·Haristi GaitantziUlrike Subotic
Nov 11, 2017·Gut·Philip N NewsomeAndrew Yeoman
Mar 17, 2018·Environmental Science and Pollution Research International·Sarva Mangala PraveenaSuresh Kumar
Jun 23, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yingying ChenPing Ma
Aug 11, 2019·Environment International·Stephanie C HammelHeather M Stapleton
Aug 14, 2019·Environment International·Ashley J MalinAlison P Sanders
Sep 14, 2019·The American Journal of Gastroenterology·Katherine DangRobert J Wong
Dec 7, 2019·Environmental Science and Pollution Research International·Nataša MiloševićMilica Medić Stojanoska
Feb 20, 2020·Environmental Research·Surabhi Shah-KulkarniEun-Hee Ha
Feb 20, 2020·Environmental Health Perspectives·Youssef OulhoteGina Muckle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.