DOI: 10.1101/511253Jan 3, 2019Paper

Associations between vascular risk factors and brain MRI indices in UK Biobank

BioRxiv : the Preprint Server for Biology
Simon R CoxIan J Deary

Abstract

Aims: Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macro- and microstructure in large community-dwelling populations across middle- and older age. Methods and Results: Associations between VRFs (smoking, hypertension, pulse pressure, diabetes, hypercholersterolaemia, BMI, and waist-hip ratio) and both global and regional brain structural and diffusion MRI markers were examined in UK Biobank (N = 9722, age range 44-77 years). A larger number of VRFs was associated with greater brain atrophy, lower grey matter volume, and poorer white matter health. Effect sizes were small (brain structural R2 ≤ 1.8%). Higher aggregate vascular risk was related to multiple regional MRI hallmarks associated with dementia risk: lower frontal and temporal cortical volumes, lower subcortical volumes, higher white matter hyperintensity volumes, and poorer white matter microstructure in association and thalamic pathways. Smoking pack years, hypertension and diabetes showed the most consistent associations across all brain measures. Hypercholesterolaemia was not uniquely associated with any MRI...Continue Reading

Related Concepts

Biological Markers
Blood Vessel
Brain
Cerebrovascular Disorders
Diabetes
Hypercholesterolemia
Hypertensive Disease
Magnetic Resonance Imaging
Temporal Lobe
Cerebral Atrophy

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