PMID: 25773805Mar 17, 2015Paper

Associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk and effect modifications of dietary calcium and vitamin D in a Japanese population

Asian Pacific Journal of Cancer Prevention : APJCP
Nobuyuki TakeshigeReiji Terasaka

Abstract

Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. In a study of 685 cases of colorectal cancer and 778 community controls in Japan, we examined the associations of the FokI, BsmI, ApaI, and TaqI polymorphisms with colorectal cancer risk and effect modification by dietary calcium and vitamin D. Genotypes were determined by the PCR-RFLP method. The ApaI polymorphism seemed to be associated with a decreased risk of colorectal cancer, particularly of rectal cancer. The adjusted odds ratio of colorectal cancer for the ApaI AA and Aa genotypes combined versus the aa genotype was 0.83 (95% confidence interval [CI] 0.67-1.02), and the corresponding value for rectal cancer was 0.75 (95%CI 0.56-0.99). A decreased risk of colorectal cancer for the ApaI AA and Aa genotypes combined was more evident in individuals with high calcium intake (interaction p=0.055). The FokI polymorphism seemed to be associated with a decreased risk of colon cancer among those with high vitamin D intake (interaction p=0.09). The BsmI and TaqI polymorphisms were unrelated to colorectal cancer risk, and the...Continue Reading

References

Feb 24, 2001·Epidemiologic Reviews·J M ZmudaR E Ferrell
Jul 18, 2001·Cancer Causes & Control : CCC·M L SlatterS Neuhausen
Apr 30, 2004·European Journal of Cancer Care·K Reuter, M Härter
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryWade Samowitz
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Jul 16, 2005·Cancer Letters·Kyungsook ParkJin Cheon Kim
Aug 22, 2006·Cancer Science·Kayoko IsomuraNobutoshi Imaizumi
Feb 14, 2007·American Journal of Preventive Medicine·Edward D GorhamMichael F Holick
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tetsuya MizoueNobutoshi Imaizumi
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Makiko MoritaNobutoshi Imaizumi
May 1, 2009·Carcinogenesis·Sara RaimondiSara Gandini
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Mar 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mathilde TouvierTeresa Norat
Apr 25, 2012·World Journal of Gastroenterology : WJG·Yong-Heng BaiBi-Cheng Chen
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Mohammadreza NassiriMohammad Doosti
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Sabha RasoolBashir Ahmad Ganai
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Makiko MoritaReiji Terasaka
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kun YuQing Lu
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Manar Fayiz Atoum, Melya Nizar Tchoporyan

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Citations

Jul 31, 2013·Progress in Histochemistry and Cytochemistry·Isabelle ClinckspoorBrigitte Decallonne
Oct 17, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lukasz LaczmanskiWojciech Witkiewicz
Aug 7, 2017·Oncology Letters·Nam Nhut PhanYen-Chang Lin
Jul 8, 2015·Journal of Cancer Prevention·Yoon Park, Jeongseon Kim

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