Associations between vitamin D status in pregnancy and offspring neurodevelopment: a systematic literature review

Nutrition Reviews
Janet JanbekBerit L Heitmann

Abstract

Vitamin D plays an important role in the development of the brain, which is one of the earliest fetal organs to develop. Results from epidemiological studies investigating associations between maternal levels of vitamin D during pregnancy and offspring neurodevelopment are mixed and inconclusive. This systematic review of studies that examined vitamin D levels in pregnancy and offspring neurodevelopment used 3 specific domains-timing of exposure during pregnancy trimesters, neurodevelopmental outcomes, and offspring age at assessment of outcomes-to determine whether vitamin D status in pregnancy is associated with offspring neurodevelopment. A search of the Embase, PsychInfo, Scopus, and The Cochrane Library databases in September 2017 and February 2018 identified 844 articles, of which 46 were retrieved for full-text assessment. Eligibility criteria were used to select studies. All authors examined the studies, and consensus was reached through discussion. Results were divided according to the 3 domains. Authors examined the studies independently, and data from eligible studies were extracted using a modified version of the Cochrane data collection form. Using the modified Downs and Black checklist, 2 authors assessed the qual...Continue Reading

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Citations

May 5, 2020·Epilepsia·Ina O SpechtBerit L Heitmann
May 7, 2020·Current Pharmaceutical Design·Giulia LisiCinzia Niolu
Nov 30, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Yvan VandenplasSulaiman Alsaad
Dec 10, 2020·Paediatric and Perinatal Epidemiology·Ellen C FrancisLior Rennert
Jun 24, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg, Melissa Cheyney

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