Associations of [18 F]-APN-1607 Tau PET Binding in the Brain of Alzheimer's Disease Patients With Cognition and Glucose Metabolism

Frontiers in Neuroscience
Jiaying LuAxel Rominger

Abstract

Molecular imaging of tauopathies is complicated by the differing specificities and off-target binding properties of available radioligands for positron emission tomography (PET). [18F]-APN-1607 ([18F]-PM-PBB3) is a newly developed PET tracer with promising properties for tau imaging. We aimed to characterize the cerebral binding of [18F]-APN-1607 in Alzheimer's disease (AD) patients compared to normal control (NC) subjects. Therefore, we obtained static late frame PET recordings with [18F]-APN-1607 and [18F]-FDG in patients with a clinical diagnosis of AD group, along with an age-matched NC group ([18F]-APN-1607 only). Using statistical parametric mapping (SPM) and volume of interest (VOI) analyses of the reference region normalized standardized uptake value ratio maps, we then tested for group differences and relationships between both PET biomarkers, as well as their associations with clinical general cognition. In the AD group, [18F]-APN-1607 binding was elevated in widespread cortical regions (P < 0.001 for VOI analysis, familywise error-corrected P < 0.01 for SPM analysis). The regional uptake in AD patients correlated negatively with Mini-Mental State Examination score (frontal lobe: R = -0.632, P = 0.004; temporal lobe: ...Continue Reading

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Citations

Jan 28, 2021·Seminars in Nuclear Medicine·Aren van WaardeRudi A J O Dierckx
May 25, 2021·Frontiers in Aging Neuroscience·Weiqi BaoYiyun Henry Huang
Jul 9, 2021·Frontiers in Neuroscience·Huiwei ZhangUNKNOWN and Alzheimer’s Disease Neuroimaging Initiative
Jun 11, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Jiaying LuChuantao Zuo
Jun 6, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Ling LiUNKNOWN Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)

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Methods Mentioned

BETA
structural magnetic resonance

Software Mentioned

Atlas
PNEURO
Talairach Daemon
OSEM
SPSS
MATLAB
SPM

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