Associations of Acid Suppressive Therapy With Cardiac Mortality in Heart Failure Patients

Journal of the American Heart Association
Akiomi YoshihisaYasuchika Takeishi

Abstract

It has been recently reported that histamine H2receptor antagonists (H2RAs) are associated with impairment of ventricular remodeling and incident heart failure. In addition, favorable pleiotropic effects and adverse effects of proton pump inhibitors (PPIs) on cardiovascular disease have also been reported. We examined the associations of acid suppressive therapy using H2RAs or PPIs with cardiac mortality in patients with heart failure. In total, 1191 consecutive heart failure patients were divided into 3 groups: a non-acid suppressive therapy group (n=363), an H2RA group (n=164), and a PPI group (n=664). In the follow-up period (mean 995 days), 169 cardiac deaths occurred. In the Kaplan-Meier analysis, cardiac mortality was significantly lower in the PPI group than in the H2RA and non-acid suppressive therapy groups (11.0% versus 21.3% and 16.8%, respectively; log-rankP=0.004). In the multivariable Cox proportional hazards analysis, use of PPIs, but not H2RAs, was found to be an independent predictor of cardiac mortality (PPIs: hazard ratio 0.488,P=0.002; H2RAs: hazard ratio 0.855,P=0.579). The propensity-matched 1:1 cohort was assessed based on propensity score (H2RAs, n=164; PPIs, n=164). Cardiac mortality was significantly l...Continue Reading

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Citations

Dec 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Akiomi Yoshihisa
Jun 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ulrike LisewskiTorsten K Roepke
Apr 11, 2019·European Journal of Preventive Cardiology·Akiomi YoshihisaYasuchika Takeishi
Dec 5, 2019·European Journal of Internal Medicine·Antonis A ManolisAntonis S Manolis
Oct 16, 2020·Molecular Phylogenetics and Evolution·Infant Sagayaraj RavheNarayanan Manoj
Oct 9, 2021·Heart Failure Reviews·Scott P Levick
Oct 29, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yu SatoYasuchika Takeishi

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