Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study

Inflammatory Bowel Diseases
Clive M OnnieC G Mathew

Abstract

Allelic variants of the ATP-binding cassette, subfamily B member 1 (ABCB1), also known as the multidrug resistance gene (MDR1) that encodes the membrane-bound efflux transporter P-glycoprotein 170 (PGP-170), have been associated with inflammatory bowel disease but with conflicting results. The present study examined the association of ABCB1 C3435T and G2677T/A in a large British case-control cohort of 828 Crohn's disease, 580 ulcerative colitis (UC) cases, and 285 healthy controls. The effect of these variants was further examined with respect to phenotypic and epidemiological characteristics. A meta-analysis was carried out of our results and those from 8 previously published association studies of the C3435T variant in inflammatory bowel disease. The 2677T allele was significantly increased in British UC cases compared with controls (45.2% vs. 39.6%; P = 0.034). In particular, the TT genotype was significantly associated with severe UC (odds ratio [OR] 1.90; 95% CI 1.01-3.55) and the use of steroids in UC (OR 1.77; 95% CI 1.08-2.88). No significant association was seen with C3435T and UC, Crohn's disease, or any clinical subgroup. A meta-analysis of 9 association studies of C3435T showed a significant association of the 3435T...Continue Reading

References

Sep 26, 1991·The New England Journal of Medicine·D K Podolsky
Jan 10, 1991·The New England Journal of Medicine·M OrholmV Binder
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J E Lennard-Jones
Mar 1, 1989·Scandinavian Journal of Gastroenterology·E KanekoN Honda
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·G J RandolphW A Muller
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J SmythR W Johnstone
Jun 11, 1999·The American Journal of Gastroenterology·B MoumK Elgjo
Jun 8, 2000·Bioinformatics·G R Abecasis, W O Cookson
Aug 15, 2001·Clinical Pharmacology and Therapeutics·R B KimG R Wilkinson
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Jun 18, 2002·Molecular Pharmacology·Chava Kimchi-SarfatyMichael M Gottesman
Jan 16, 2004·Gastroenterology·Jürgen GlasChristian Folwaczny
Feb 21, 2004·Human Molecular Genetics·David A van HeelUNKNOWN Genome Scan Meta-Analysis Group of the IBD International Genetics Consortium
Feb 21, 2004·Human Molecular Genetics·Kun TangCaroline G L Lee
Sep 6, 2005·Pharmacogenetics and Genomics·Danxin WangWolfgang Sadée
Oct 22, 2005·Inflammatory Bowel Diseases·Gwo-Tzer HoJack Satsangi

❮ Previous
Next ❯

Citations

Dec 11, 2008·Inflammatory Bowel Diseases·Elizabeth M StaleyRobin G Lorenz
Aug 1, 2007·European Journal of Clinical Pharmacology·T FiedlerA Johne
Aug 9, 2007·PloS One·Andre FrankeStefan Schreiber
Jul 4, 2008·Pharmacogenomics·Helga-Paula TörökAstrid Konrad
Mar 20, 2010·Pharmacogenomics·Melissa A SmithJeremy D Sanderson
May 31, 2011·Pharmacogenomics·Bruno Stieger, Peter J Meier
Jul 6, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mortaza J BonyadiManouchehr Khoshbaten
Oct 6, 2009·Journal of Gastroenterology·Shunji IshiharaYoshikazu Kinoshita
May 6, 2009·Best Practice & Research. Clinical Gastroenterology·Casper G NoomenHerma H Fidder
Jul 14, 2007·Mutation Research·Lynnette R FergusonIvonne Petermann
Nov 4, 2006·Alimentary Pharmacology & Therapeutics·K R Herrlinger, D P Jewell
Mar 3, 2009·American Journal of Human Genetics·Kai WangHakon Hakonarson
Feb 26, 2015·Pharmacological Reports : PR·Ewa Jaźwińska-TarnawskaAnna Wiela-Hojeńska
May 12, 2016·The Pharmacogenomics Journal·K van der WeideJ van der Weide
Feb 25, 2009·Inflammatory Bowel Diseases·Rachel CooneyDerek P Jewell
Jan 30, 2007·Inflammatory Bowel Diseases·S ArdizzoneG Bianchi Porro
Jan 9, 2007·Inflammatory Bowel Diseases·Johan Van LimbergenJack Satsangi
Sep 27, 2007·The American Journal of Gastroenterology·Johan Van LimbergenJack Satsangi
Sep 4, 2012·Journal of Clinical Gastroenterology·Lisa GruberDirk Haller
Nov 28, 2018·JAD Reports·Richard Lathe, Jean-Luc Darlix
Nov 4, 2015·World Journal of Gastroenterology : WJG·Gonzalo Jesús Gómez-GómezBegoña Casís
Jan 23, 2014·Molecular Biology Reports·Jun WangWeiguo Dong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.