Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction

Clinical Chemistry and Laboratory Medicine : CCLM
Larry BaumKam Sang Woo

Abstract

Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease. We performed a case-control study of 816 subjects: 246 acute ischemic stroke patients, 234 acute myocardial infarction patients, and 336 controls. APOE exon 4 and LPL S447X genotypes were determined. APOE epsilon2 and epsilon4 homozygotes were increased in stroke (4.5% vs. 1.0%, p = 0.008), while in myocardial infarction the epsilon4 allele was increased (12.6% vs. 9.5%, p = 0.006) but epsilon2 was decreased (3.7% vs. 12.1%, p = 0.000006). For subjects with either APOE epsilon2 or epsilon4 alleles, LPL X alleles were increased in vascular disease (OR = 2.2, p = 0.01). LPL X alleles displayed opposite tendencies toward association with disease when subjects were divided by sex, smoking, or APOE genotype. Meta-analysis and regression analysis of previous studies supported the sex and smoking dichotomies. This is the first report of an association of vascular disease with an interaction of APOE exon 4 and LPL S447X genotypes. Therefore, APOE genotypes and LPL S447X interaction...Continue Reading

References

Jan 1, 1979·Acta Medica Scandinavica·M McCallL Wilhelmsen
Jul 1, 1989·Journal of Endocrinological Investigation·M D DamewoodJ A Rock
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Nov 1, 1971·Lancet·T FyfeE M Booth
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·P W WilsonJ M Ordovas
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·Y Shimo-NakanishiY Mizuno
Mar 29, 2002·Genetic Epidemiology·Alanna C MorrisonEric Boerwinkle
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Adam E MullickJohn C Rutledge
Feb 21, 2003·Angiology·Genovefa KolovouDimitri P Mikhailidis
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shui-Ping ZhaoShai Nie
May 16, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Goran FerencakAna Stavljenić Rukavina
Dec 23, 2003·Diabetes, Obesity & Metabolism·Philippa J Talmud, Jeffrey W Stephens

❮ Previous
Next ❯

Citations

Feb 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing GuanJuliana C N Chan
Dec 13, 2012·Annals of the Rheumatic Diseases·Maša Umiċeviċ MirkovMarieke J H Coenen
Nov 4, 2009·Occupational and Environmental Medicine·Jaime MadriganoJoel Schwartz
Sep 13, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Anca SimaCamelia Stancu
Mar 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuliana Fortunato, Maria D Di Taranto
Jan 29, 2008·Expert Opinion on Pharmacotherapy·Cornelia Remmler, Ingolf Cascorbi
Apr 19, 2008·Human Mutation·A BersanoL Candelise
Jul 2, 2010·Critical Reviews in Clinical Laboratory Sciences·Sanja Stankovic, Nada Majkic-Singh
Dec 12, 2013·Expert Review of Clinical Pharmacology·Enrico CocchiAlessandro Serretti
Jun 22, 2021·Genetic Testing and Molecular Biomarkers·Kunhui HeYongheng Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.