Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)

PloS One
Brendan J GuercioCharles S Fuchs

Abstract

Observational studies have demonstrated increased colon cancer recurrence and mortality in states of excess energy balance, as denoted by factors including sedentary lifestyle, diabetes, increased dietary glycemic load, and increased intake of sugar-sweetened beverages. Nonetheless, the relation between artificially sweetened beverages, a popular alternative for sugar-sweetened beverages, and colon cancer recurrence and survival is unknown. We analyzed data from 1,018 patients with stage III colon cancer who prospectively reported dietary intake during and after chemotherapy while enrolled in a National Cancer Institute-sponsored trial of adjuvant chemotherapy. Using Cox proportional hazards regressions, we assessed associations of artificially sweetened beverage intake with cancer recurrence and mortality. Patients consuming one or more 12-ounce servings of artificially sweetened beverages per day experienced an adjusted hazard ratio for cancer recurrence or mortality of 0.54 (95% confidence interval, 0.36 to 0.80) when compared to those who largely abstained (Ptrend = .004). Similarly, increasing artificially sweetened beverage intake was also associated with a significant improvement in both recurrence-free survival (Ptrend ...Continue Reading

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Citations

Oct 12, 2020·Canadian Journal of Diabetes·Fausto PetrelliAntonio Carlo Bossi
Jun 12, 2021·The Journal of Nutrition·Andrea Romanos-NanclaresA Heather Eliassen
Nov 13, 2021·JAMA Network Open·Yiqing WangAndrew T Chan

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Methods Mentioned

BETA
surgical resection
PCR

Clinical Trials Mentioned

NCT00003835

Software Mentioned

SAS

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