Associations of birth defects with adult intellectual performance, disability and mortality: population-based cohort study

Pediatric Research
Martha G EideNina Oyen

Abstract

Infants born with birth defects have poorer outcomes in terms of mortality and disability, but the long-term intellectual outcome in children with birth defects is generally unknown. We assessed the long-term associations of various birth defects with mortality and disability, and evaluated whether high mortality and disability were reflected in impaired intellectual performance at age 18. In this nationwide cohort study, records of 9,186 males with and 384,384 without birth defects, registered in the Medical Birth Registry of Norway (1967-1979) were linked to the National Conscript Service (1984-1999). Mortality and disability before military draft, and intelligence test score at conscription were the main outcome measures. Males with birth defects had a relative risk for disability of 6.0 compared with males without defects. Disability was low within categories of birth defects associated with low mortality, and high within defect categories associated with high mortality. The relative risk for not being drafted was highest if maternal educational level was low. Heart defects and cleft palate were the only subgroups in which intellectual performance was lower after adjustment for maternal education, maternal age, marital stat...Continue Reading

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Citations

Jun 14, 2013·Cardiology in the Young·Manavi TyagiStanton P Newman
Mar 28, 2012·Journal of Pediatric Psychology·Rachel M RobertsPatricia Wheaton
Jan 11, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Martin PerssonHenry Svensson
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Nov 6, 2014·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Nicola Marie StockNichola Rumsey
Jan 23, 2016·Psychology & Health·Nicola Marie Stock, Kristin Billaud Feragen
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Oct 19, 2016·Cardiology in the Young·Manavi TyagiStanton P Newman
Jan 20, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Martin PerssonHenry Svensson
Aug 10, 2016·Child: Care, Health and Development·J C BellN Nassar
Oct 4, 2019·Birth Defects Research·Cara T MaiUNKNOWN National Birth Defects Prevention Network
May 30, 2020·Scandinavian Journal of Public Health·Elin A FadumEinar K Borud
Aug 19, 2015·Pediatrics·Tiffany Riehle-ColarussoAdolfo Correa

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Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.