Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes

Environmental Health Perspectives
B K LeeB S Schwartz

Abstract

Evidence suggests that lead and selected genes known to modify the toxicokinetics of lead--namely, those for the vitamin D receptor (VDR) and delta-aminolevulinic acid dehydratase (ALAD)--may independently influence blood pressure and hypertension risk. We report the relations among ALAD and VDR genotypes, three lead dose measures, and blood pressure and hypertension status in 798 Korean lead workers and 135 controls without occupational exposure to lead. Lead dose was assessed by blood lead, tibia lead measured by X-ray fluorescence, and dimercaptosuccinic acid (DMSA)-chelatable lead. Among lead workers, 9.9% (n = 79) were heterozygous for the ALAD(2) allele, and there were no ALAD(2) homozygotes; 11.2% (n = 89) had at least one copy of the VDR B allele, and 0.5% (n = 4) had the BB genotype. In linear regression models to control for covariates, VDR genotype (BB and Bb vs. bb), blood lead, tibia lead, and DMSA-chelatable lead were all positive predictors of systolic blood pressure. On average, lead workers with the VDR B allele, mainly heterozygotes, had systolic blood pressures that were 2.7-3.7 mm Hg higher than did workers with the bb genotype. VDR genotype was also associated with diastolic blood pressure; on average, lead...Continue Reading

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Citations

Jul 29, 2003·Occupational and Environmental Medicine·V M WeaverB S Schwartz
Aug 4, 2004·Environmental Health Perspectives·Charles LinHoward Hu
Jan 1, 2005·Environmental Health Perspectives·Virginia M WeaverByung-Kook Lee
Apr 14, 2007·Environmental Health Perspectives·Brian S Schwartz, Howard Hu
Apr 14, 2007·Environmental Health Perspectives·Ana Navas-AcienStephen J Rothenberg
Aug 10, 2007·Environmental Health Perspectives·Junenette L PetersHoward Hu
May 31, 2008·American Journal of Public Health·Keson TheppeangBrian S Schwartz
Dec 10, 2009·Archives of General Psychiatry·Maryse F BouchardMarc G Weisskopf
Feb 4, 2010·Environmental Health Perspectives·Franco ScinicarielloUNKNOWN Centers for Disease Control and Prevention/National Cancer Institute National Health and Nutrition Examination Survey III Ge
Aug 13, 2004·American Journal of Industrial Medicine·Cuauhtémoc Arturo Juárez-PérezMauricio Hernández-Avila
May 31, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Jina KimMihi Yang
Jul 27, 2011·Environmental Toxicology and Pharmacology·Rafał PorębaRyszard Andrzejak
Oct 30, 2007·Journal of Toxicology and Environmental Health. Part a·Yang ZhaoFeng Chen
Aug 15, 2006·Epidemiology·Barbara S GlennBrian S Schwartz
Apr 17, 2008·Epidemiology·Ana Navas-AcienEliseo Guallar
Jul 26, 2007·Archives of Environmental & Occupational Health·Winai WananukulPorntip Salaitanawatwong
Mar 6, 2008·American Journal of Industrial Medicine·Virginia M WeaverBrian S Schwartz
Sep 25, 2020·International Journal of Environmental Research and Public Health·Garam ByunJong-Tae Lee
May 24, 2019·Human & Experimental Toxicology·M S ManiH S Dsouza
Mar 21, 2007·Environmental Health Perspectives·Franco ScinicarielloBruce A Fowler

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