Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer's disease.

Translational Neurodegeneration
Mari AksnesAnne-Brita Knapskog

Abstract

The aggregation of amyloid β (Aβ) is central in the pathogenesis of Alzheimer's disease (AD). Recently it has been shown that specifically, larger, Thioflavin T-binding Aβ aggregates are associated with increased neuroinflammation and cytokine release. This study was aimed to quantify fibrillary amyloid aggregates, so-called nanoplaques, and investigate their relationship with cytokines in the cerebrospinal fluid (CSF). CSF was collected from 111 patients assessed for cognitive complaints at the Oslo University Hospital Memory Clinic. The patients were grouped based on their amyloid status. The CSF nanoplaque concentration was quantified with the Thioflavin T-fluorescence correlation spectroscopy (ThT-FCS) assay. The levels of nine cytokines (eotaxin-1, granulocyte stimulating factor, interleukin [IL]-6, IL-7, IL-8, monocyte chemoattractant protein-1, gamma-induced protein 10, macrophage inflammatory protein [MIP]-1α, and MIP-1β) were quantified with a magnetic bead-based multiplex assay and read on a Luminex IS 200 instrument. There were 49 amyloid-negative and 62 amyloid-positive patients in the cohort; none of the cytokines differed significantly between the amyloid groups. The increased nanoplaque levels were associated wit...Continue Reading

References

Mar 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KossmannM C Morganti-Kossmann
Oct 18, 2000·Journal of Neurochemistry·A V Andjelkovic, J S Pachter
Jun 11, 2003·The Journal of Experimental Medicine·Joseph B El KhouryAndrew D Luster
Apr 16, 2005·Neuro-oncology·Daniel J BratErwin G Van Meir
Jul 12, 2005·The Journal of Clinical Investigation·Armin SchneiderWolf-Rüdiger Schäbitz
May 13, 2006·Journal of Geriatric Psychiatry and Neurology·M RentzosD Vassilopoulos
Jul 18, 2006·Journal of the Neurological Sciences·Michael RentzosDemetris Vassilopoulos D
Apr 13, 2007·Neuro-degenerative Diseases·Verena H Finder, Rudi Glockshuber
Oct 22, 2008·The International Journal of Neuroscience·P AngelopoulosS I Baloyiannis
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Vladana VukojevicRudolf Rigler
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Andrea VarroneUNKNOWN European Association of Nuclear Medicine Neuroimaging Committee
Feb 26, 2011·The Journal of Biological Chemistry·Suman NagSudipta Maiti
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Nov 17, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Anne BrækhusKnut Engedal
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Alberto Serrano-PozoBradley T Hyman
Feb 26, 2014·Molecular Neurobiology·Frederic BrosseronMichael T Heneka
Mar 19, 2014·Alzheimer Disease and Associated Disorders·Perminder SachdevUNKNOWN Internationlal Society for Vascular Behavioral and Cognitive Disorders
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Mar 11, 2015·Journal of Internal Medicine·D FerreiraUNKNOWN AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
Aug 19, 2015·Brain : a Journal of Neurology·Heiko Braak, Kelly Del Tredici
Mar 31, 2016·EMBO Molecular Medicine·Dennis J Selkoe, John Hardy
Sep 28, 2016·BMC Neurology·Raphael HesseChristine A F von Arnim
Jan 27, 2017·Brain : a Journal of Neurology·Zhen FanPaul Edison
Apr 23, 2017·Journal of the Neurological Sciences·Eva BagyinszkySangYun Kim
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Aug 21, 2018·Frontiers in Cellular Neuroscience·Si-Hao DuHuijun Wang
Sep 27, 2018·Nature Neuroscience·Claudio Soto, Sandra Pritzkow
Jan 12, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Xue-Ning ShenJin-Tai Yu

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