Associations of childhood BMI and change in BMI from childhood to adulthood with risks of hypertensive disorders in pregnancy

The American Journal of Clinical Nutrition
Dorthe C PedersenJennifer L Baker

Abstract

Maternal overweight (including obesity) is an established risk factor for gestational hypertension and pre-eclampsia. However, it is largely unknown whether body size before adulthood relates to these diseases. We examined whether childhood BMI (in kg/m2) and changes in BMI from childhood to adulthood were associated with gestational hypertension and pre-eclampsia. Using the Copenhagen School Health Records Register, we studied 49,600 women born between 1940 and 1996 with height and weight measurements at 7 y and/or 13 y who had their first singleton birth between ages 18 and 45 y. Women with gestational hypertension (n = 496) and pre-eclampsia (n = 1804) were identified from the International Classification of Disease codes in the Danish National Patient Register. Adult overweight (including obesity) was defined as a BMI ≥25. We used log-linear binomial regression to estimate risk ratios (RRs) and 95% CIs. At 13 y, as BMI increased above average (z score >0, or the 42nd percentile of the CDC BMI reference), RR for gestational hypertension was 1.66 (95% CI: 1.42, 1.94) and that for pre-eclampsia was 1.57 (95% CI: 1.46, 1.70) per BMI z score. In a subset of 13,160 women, development of overweight from childhood to adulthood and ...Continue Reading

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Citations

Nov 5, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giorgina Barbara PiccoliUNKNOWN Kidney and Pregnancy Study Group of the Italian Society of Nephrology (Giuseppe Gernone, Domenico Santoro, Gabriella Moroni,

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