Abstract
Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear. We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study. CAC density was calculated as mass divided by volume, and associations with incident all-cause and CVD mortality [median follow-up 10.2 years European Americans (n = 902, n = 286 deceased), 5.2 years African Americans (n = 552, n = 93 deceased)] were examined using Cox proportional hazards models, independently and in models adjusted for CAC volume. In European Americans, CAC density, like Agatston score and volume, was consistently associated with increased risk of all-cause and CVD mortality (p ≤ 0.002) in models adjusted for age, sex, statin use, total cholesterol, HDL, systolic blood pressure, high blood pressure medication use, and current smoking. However, these ...Continue Reading
References
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Oct 15, 1995·Circulation·J A RumbergerR S Schwartz
Aug 1, 1996·AJR. American Journal of Roentgenology·L S BroderickK K Kopecky
Sep 18, 1997·Investigative Radiology·J ShemeshM Motro
Apr 5, 2000·AJR. American Journal of Roentgenology·J J CarrG L Burke
Feb 13, 2001·Journal of Clinical Epidemiology·S A CoadyD E Conwill
Feb 4, 2003·Radiology·Joseph ShemeshMichael Motro
Feb 7, 2003·Journal of the American College of Cardiology·Timothy C LeeAllen J Taylor
Mar 26, 2003·Journal of the American College of Cardiology·Julie Anne HoffGeorge T Kondos
Jul 19, 2003·Radiology·Leslee J ShawTracy Q Callister
Dec 25, 2004·Radiology·J Jeffrey CarrRobert C Detrano
Mar 17, 2005·Circulation·Diane E BildMohammed F Saad
Nov 2, 2005·Diabetologia·B I FreedmanL E Wagenknecht
May 12, 2007·American Journal of Epidemiology·Lynne E WagenknechtDonald W Bowden
Oct 30, 2007·Bone·J Jeffrey CarrBarry I Freedman
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Apr 17, 2008·Radiology·Elizabeth R BrownRobert Detrano
Jan 1, 2008·JACC. Cardiovascular Imaging·Marcus WilliamsMatthew Budoff
Apr 29, 2010·JAMA : the Journal of the American Medical Association·Tamar S PolonskyPhilip Greenland
Jul 17, 2010·JACC. Cardiovascular Imaging·Kaori InoueYukio Ozaki
Oct 16, 2010·Journal of the American College of Cardiology·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Mar 15, 2011·Diabetes Care·Subhashish AgarwalDonald W Bowden
Sep 21, 2011·Atherosclerosis·Megan CoylewrightWendy S Post
Jul 4, 2012·BMC Medical Imaging·C Jason LiangElizabeth R Brown
Jul 5, 2012·Acta Radiologica·Tapio Vehmas
Dec 12, 2012·Diabetes Care·Subhashish AgarwalDonald W Bowden
Dec 13, 2012·Circulation. Cardiovascular Genetics·Jasmin DiversBarry I Freedman
Mar 27, 2013·BMJ : British Medical Journal·Caroline K KramerRavi Retnakaran
Nov 6, 2013·Cardiovascular Diabetology·Joseph ShemeshEhud Grossman
Nov 20, 2013·JAMA : the Journal of the American Medical Association·Michael H CriquiMatthew A Allison
Nov 26, 2013·Atherosclerosis·Irfan ZebMatthew Budoff
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jul 6, 2014·Diabetes Care·Amanda J CoxDonald W Bowden
Aug 26, 2014·Atherosclerosis·Joseph YeboahPhilip Greenland
Jan 15, 2015·Atherosclerosis·Krishna AlluriMichael J Blaha
Mar 7, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Samson Y GebreabSharon K Davis
Mar 15, 2015·International Journal of Cardiology·Michael HeneinPaolo Raggi
Jun 13, 2015·Clinical Imaging·Yu HtweDavid F Yankelevitz
Feb 15, 2017·JAMA Cardiology·John Jeffrey CarrDavid C Goff
Aug 12, 2017·JACC. Cardiovascular Imaging·Michael H CriquiMatthew A Allison
Citations
Jun 23, 2019·Medical Physics·Yuankai HuoBennett A Landman
Apr 3, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Yabing ChenHui Wu
Dec 12, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hideyuki MukaiPeter Stenvinkel
Aug 28, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paraskevi TaxiarchiMamas A Mamas
Oct 30, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Yabing ChenHui Wu
Nov 24, 2020·Cardiovascular Endocrinology & Metabolism·Mouhamed NashawiRobert Chilton
Apr 24, 2021·World Journal of Diabetes·Jake RajbhandariJoseph M Pappachan
Jul 13, 2021·Frontiers in Physiology·Yifen LinXinxue Liao