Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study

Cardiovascular Diabetology
Laura M RaffieldDonald W Bowden

Abstract

Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear. We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study. CAC density was calculated as mass divided by volume, and associations with incident all-cause and CVD mortality [median follow-up 10.2 years European Americans (n = 902, n = 286 deceased), 5.2 years African Americans (n = 552, n = 93 deceased)] were examined using Cox proportional hazards models, independently and in models adjusted for CAC volume. In European Americans, CAC density, like Agatston score and volume, was consistently associated with increased risk of all-cause and CVD mortality (p ≤ 0.002) in models adjusted for age, sex, statin use, total cholesterol, HDL, systolic blood pressure, high blood pressure medication use, and current smoking. However, these ...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Feb 7, 2003·Journal of the American College of Cardiology·Timothy C LeeAllen J Taylor
Mar 26, 2003·Journal of the American College of Cardiology·Julie Anne HoffGeorge T Kondos
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Jan 1, 2008·JACC. Cardiovascular Imaging·Marcus WilliamsMatthew Budoff
Apr 29, 2010·JAMA : the Journal of the American Medical Association·Tamar S PolonskyPhilip Greenland
Oct 16, 2010·Journal of the American College of Cardiology·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Dec 12, 2012·Diabetes Care·Subhashish AgarwalDonald W Bowden
Dec 13, 2012·Circulation. Cardiovascular Genetics·Jasmin DiversBarry I Freedman
Nov 20, 2013·JAMA : the Journal of the American Medical Association·Michael H CriquiMatthew A Allison
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 7, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Samson Y GebreabSharon K Davis
Mar 15, 2015·International Journal of Cardiology·Michael HeneinPaolo Raggi

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Citations

Apr 3, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Yabing ChenHui Wu
Dec 12, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hideyuki MukaiPeter Stenvinkel
Aug 28, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paraskevi TaxiarchiMamas A Mamas
Nov 24, 2020·Cardiovascular Endocrinology & Metabolism·Mouhamed NashawiRobert Chilton
Apr 24, 2021·World Journal of Diabetes·Jake RajbhandariJoseph M Pappachan

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Methods Mentioned

BETA
urine collection
coronary artery bypass

Software Mentioned

Healthcare Smartscore
MESA
GE

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