Associations of cytokine levels in gingival crevicular fluid of mobile teeth with clinical improvement after initial periodontal treatment

Journal of Oral Science
Shingo KasaiKeisuke Nakashima

Abstract

Studies suggest that analysis of gingival crevicular fluid (GCF) is useful for evaluating periodontal status. In this study, clinical variables related to tooth mobility, and multiple cytokine levels in proximate GCF, were measured at four time points during initial periodontal treatment: before treatment (baseline), after supragingival scaling, after occlusal adjustment, and after scaling and root planing (SRP); 20 teeth from 13 patients with periodontitis were included. Baseline interleukin (IL)-10 level in GCF was significantly higher around teeth that showed substantial improvement in periodontal epithelial surface area (PESA) after SRP than around teeth without PESA improvement. IL-3 and IL-16 levels in GCF at baseline were significantly higher around teeth with a periodontal inflamed surface area (PISA) of 0 mm2 after SRP than around teeth without PISA improvement. In addition, baseline IL-7, IL-11, and IL-12p40 levels in GCF were significantly lower around teeth with decreased mobility after occlusal adjustment than around teeth without decreased mobility. These results suggest that pre-treatment cytokine levels in GCF are useful in predicting the effects of initial periodontal treatment.

References

Jul 1, 1991·Journal of Periodontal Research·P M Bartold, D R Haynes
Dec 1, 1982·Cellular Immunology·L W PoulterG Panayi
Sep 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K YamazakiK Hara
Apr 1, 1994·The Journal of Clinical Investigation·G GirasoleS C Manolagas
Mar 1, 1993·Journal of Clinical Periodontology·R A ReinhardtA C Allison
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Okada, S Murakami
Apr 8, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D T Graves
Jun 24, 1999·Cytokine & Growth Factor Reviews·R HofmeisterS K Durum
Sep 13, 2000·Journal of Clinical Periodontology·J GamonalA Silva
Dec 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gianluca ToraldoM Neale Weitzmann
Mar 18, 2004·Journal of Periodontology·R B JohnsonF G Serio
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·M Maurer, E von Stebut
May 12, 2005·Cytokine·I-San TsaiChun-Cheng Hung
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
May 5, 2006·Journal of Periodontology·Akihiko SakaiKoichi Ito
Nov 8, 2006·The Journal of Experimental Medicine·Kojiro SatoHiroshi Takayanagi
Jun 20, 2008·Journal of Clinical Periodontology·Willem NesseArjan Vissink
Sep 4, 2008·Journal of Periodontology·Dana Graves
Jan 5, 2011·Journal of Clinical Periodontology·Keelen D TymkiwJanet M Guthmiller
Feb 12, 2013·Archives of Oral Biology·Yasuko ShimadaHiromasa Yoshie
May 2, 2013·Journal of Indian Society of Periodontology·Ronaldo Lira-JúniorRoberto Lira de Brito
Jan 31, 2017·Archives of Oral Biology·Livia NunesJonas Capelli

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Citations

Mar 7, 2021·Journal of Clinical Medicine·Yoshiaki NomuraTaneaki Nakagawa

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