Associations of Dehydroepiandrosterone Sulfate With Cardiometabolic Risk Factors in Prepubertal Children

The Journal of Clinical Endocrinology and Metabolism
Aino MäntyselkäJarmo Jääskeläinen

Abstract

Premature adrenarche (PA) has been associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulfate (DHEAS) concentration with other cardiometabolic risk factors are uncertain. To examine the associations of serum DHEAS concentration with several cardiometabolic risk factors in children. Cross-sectional data from the Physical Activity and Nutrition in Children Study. Population sample of 207 girls and 225 boys aged 7.6 ± 0.4 years. Cardiometabolic risk factors by serum DHEAS concentration. DHEAS correlated positively with body mass index standard deviation score, body fat percentage, lean body mass, high-sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT) when adjusted for age and sex. The associations of DHEAS with hs-CRP and ALT disappeared when adjusted also for body fat percentage. When further adjusted for birth weight SD score, DHEAS correlated negatively with low-density lipoprotein (LDL) cholesterol and LDL/high-density lipoprotein (HDL) cholesterol ratio. LDL cholesterol was lower in children with DHEAS ≥40 µg/dL than in those with DHEAS <40 µg/dL, adjusted for age, sex, and body fat percentage (86.5 vs 92.3 mg/dL, P = 0.029). This association stren...Continue Reading

Associated Clinical Trials

References

Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·D Crook, M Seed
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
Feb 1, 1988·The Journal of Clinical Endocrinology and Metabolism·R SorvaM R Taskinen
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Michelle R DenburgSharon E Oberfield
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Hiroaki KawanoHisao Ogawa
Mar 11, 2004·Clinical Endocrinology·Richard J Auchus, William E Rainey
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ken K OngUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Jul 14, 2004·European Journal of Endocrinology·André Tchernof, Fernand Labrie
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Dennis T Villareal, John O Holloszy
Feb 8, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Ayla GüvenAysun Bideci
Dec 17, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anna BłogowskaBarbara Krzyzanowska-Swiniarska
Dec 21, 2006·The Journal of Clinical Endocrinology and Metabolism·Robert L Rosenfield
Aug 19, 2007·The Journal of Clinical Endocrinology and Metabolism·Pauliina UtriainenRaimo Voutilainen
May 27, 2008·Metabolism: Clinical and Experimental·Revi P MathewWilliam E Russell
Jan 20, 2009·European Journal of Endocrinology·Pauliina UtriainenJarmo Jääskeläinen
Feb 24, 2009·The Journal of Pediatrics·Pauliina UtriainenJarmo Jääskeläinen
Oct 2, 2009·The American Journal of Clinical Nutrition·Lijie ShiThomas Remer
Mar 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Susan R DavisFrank Z Stanczyk
Apr 6, 2011·Hormone Research in Pædiatrics·Karina de FerranMarilia Martins Guimarães
Apr 28, 2011·Clinical Endocrinology·Marie-Hélène Gannagé-YaredLeila Abs
Jan 4, 2013·The American Journal of Clinical Nutrition·Camila CorvalánVerónica Mericq
Jun 14, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Raimo Voutilainen, Jarmo Jääskeläinen
Jul 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Aino MäntyselkäTimo A Lakka
Oct 30, 2015·Hormone Research in Pædiatrics·Kristen M WilliamsAviva B Sopher
Dec 27, 2015·The Journal of Pediatrics·Mona A EissaDarwin R Labarthe
Nov 22, 2016·Hormone Research in Pædiatrics·Nurullah ÇelikErhan Berk
Dec 16, 2016·Hormone Research in Pædiatrics·Verónica MericqCamila Corvalán
Nov 23, 2017·Frontiers in Endocrinology·Jani LiimattaJarmo Jääskeläinen

❮ Previous
Next ❯

Citations

Aug 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Jae Hyun KimChoong Ho Shin
Jun 15, 2019·Metabolomics : Official Journal of the Metabolomic Society·Oscar Daniel Rangel-HuertaAngel Gil
May 2, 2021·Archives of Disease in Childhood·Anne-Lise GoddingsGeorge C Patton
Apr 1, 2021·Endocrine Reviews·Robert L Rosenfield
Oct 14, 2020·Current Pharmaceutical Design·Sarantis LivadasDjuro Macut

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.