Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study

The American Journal of Clinical Nutrition
Maija Pt YlilauriJyrki K Virtanen

Abstract

Moderate egg intake has been associated with better cognitive performance in observational studies. This association may be due to the rich content of choline, especially phosphatidylcholine, in eggs because choline has been suggested to have a role in the prevention of cognitive decline. We investigated the associations of dietary choline intake with the risk of incident dementia and with cognitive performance in middle-aged and older men in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study. A population-based sample of 2497 dementia-free men aged 42-60 y was examined in 1984-1989. A subset of 482 men completed 5 different cognitive performance tests 4 y later. Dementia and Alzheimer disease diagnoses were retrieved from Finnish health registers. Dietary intakes were assessed with the use of 4-d food records at baseline. Cox regression and ANCOVA were used for the analyses. All analyses were also stratified by the apolipoprotein E phenotype (APOE-ε4 compared with other phenotypes). These data were available for 1259 men. The mean ± SD total choline intake was 431 ± 88 mg/d, of which 188 ± 63 mg/d was phosphatidylcholine. During a 21.9-y follow-up, 337 men were diagnosed with dementia. Those in ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1995·International Psychogeriatrics·K JuvaR Tilvis
May 1, 1996·Archives of Neurology·P A SpiersR J Wurtman
May 23, 2008·The Journal of Nutritional Biochemistry·Christian M AbratteMarie A Caudill
Dec 17, 2009·European Journal of Nutrition·Aránzazu Aparicio VizueteRosa María Ortega
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Nov 26, 2013·Neuron·Costantino Iadecola
Mar 13, 2014·Journal of Internal Medicine·A SolomonM Kivipelto
Feb 5, 2015·The Journal of Nutrition, Health & Aging·X ZhaoR Xiao
Aug 15, 2015·Annual Review of Microbiology·Gwen FalonyJeroen Raes
Jan 23, 2016·Archives of Gerontology and Geriatrics·Li DongLinhong Yuan
Oct 21, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Diede FennemaElizabeth A Shephard
Sep 3, 2016·BMC Systems Biology·Rong Xu, QuanQiu Wang
Sep 8, 2016·Cerebral Cortex·Yasaman MalekizadehJenni Harvey
Sep 17, 2016·Nutrition Reviews·Francesca PistollatoMaurizio Battino
Apr 5, 2017·Journal of Alzheimer's Disease : JAD·Chunmei JiangBin Zhao
Nov 3, 2017·The American Journal of Clinical Nutrition·Lora L IannottiChristine P Stewart
Feb 17, 2018·Journal of the American College of Nutrition·Taylor C Wallace

❮ Previous
Next ❯

Citations

Sep 20, 2019·The American Journal of Clinical Nutrition·Thomas B Shea
May 21, 2020·The American Journal of Clinical Nutrition·Karen M O'Callaghan, Daniel E Roth
Nov 23, 2019·International Journal of Molecular Sciences·Rita Moretti, Costanza Peinkhofer
Jan 21, 2021·Stroke; a Journal of Cerebral Circulation·Chongke ZhongYonghong Zhang
May 28, 2021·Frontiers in Nutrition·Amanda E BriesElizabeth M McNeill
Nov 30, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Ruopeng AnNaiman Khan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.