Associations of endogenous sex hormones with the vasculature in menopausal women: the Study of Women's Health Across the Nation (SWAN).

Menopause : the Journal of the North American Menopause Society
Rachel P WildmanKim Sutton-Tyrrell

Abstract

As associations between endogenous sex hormones and the vasculature are not well characterized, the objective was to examine the cross-sectional associations of menopausal status and endogenous sex hormones with vascular characteristics. Common carotid artery adventitial diameter and intima-media thickness were determined using B-mode ultrasonography among 483 middle-aged women enrolled in the Pittsburgh and Chicago sites of the Study of Women's Health Across the Nation. Sixty-two percent of women were pre- or early perimenopausal (<3 mo amenorrhea), 12% were late perimenopausal (3-12 mo amenorrhea), and 27% were postmenopausal (>or=12 mo amenorrhea). After adjustment for age, compared with pre-/early perimenopause, late perimenopause was associated with a 0.28-mm larger adventitial diameter (P=0.001), whereas postmenopause was associated with a 0.15-mm larger adventitial diameter (P=0.040). Adjustment for traditional cardiovascular risk factors slightly attenuated these associations, but the association with late perimenopause remained statistically significant (P=0.001). Each SD lower log estradiol value was associated with a 0.07-mm larger adventitial diameter after adjustment for traditional cardiovascular risk factors (P=0...Continue Reading

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Citations

Dec 17, 2011·Lancet Neurology·Lynda Lisabeth, Cheryl Bushnell
Mar 15, 2008·Menopause : the Journal of the North American Menopause Society·Emily D Szmuilowicz, Ellen W Seely
May 12, 2010·Menopause : the Journal of the North American Menopause Society·Susan E ApptJay R Kaplan
Jul 10, 2010·Menopause : the Journal of the North American Menopause Society·Claudio N Soares, Pauline M Maki
Nov 26, 2010·Menopause : the Journal of the North American Menopause Society·Genevieve A WoodardKim Sutton-Tyrrell
Jan 19, 2011·Menopause : the Journal of the North American Menopause Society·Rebecca C ThurstonKaren A Matthews
Jan 27, 2011·Menopause : the Journal of the North American Menopause Society·Emily D Szmuilowicz, JoAnn E Manson
Sep 6, 2011·Menopause : the Journal of the North American Menopause Society·Genevieve A WoodardKim Sutton-Tyrrell
Sep 20, 2012·Menopause : the Journal of the North American Menopause Society·Samar R El KhoudaryKim Sutton-Tyrrell
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