Associations of female exposure to bisphenol A with fecundability: Evidence from a preconception cohort study

Environment International
Bin WangShanghai Birth Cohort Study

Abstract

Human exposure to bisphenol A (BPA) is common. The reproductive toxicity of BPA has been well characterized. However, the impact of BPA exposure on fecundability in healthy women is less clear, and evidence from eastern countries is lacking. We aimed to prospectively assess the associations of BPA with female fecundability, as measured by time to pregnancy (TTP). From 2013 to 2015, we included 700 Chinese couples attempting pregnancy in two preconception care clinics and followed for 12 months or until a pregnancy occurred. The concentrations of BPA were determined in preconception urine samples of female partners. Cox's proportional models for discrete survival time were used to estimate fecundability odds ratios (FORs). Odds ratios (ORs) for infertility (TTP > 12 months) were estimated using logistic regression models. After adjusting for potential confounders, each ln-unit increase in urinary concentrations of BPA was associated with a 13% reduction in fecundability (FOR = 0.87; 95% CI: 0.78, 0.98) and a 23% increase in odds of infertility (OR = 1.23; 95% CI: 1.00, 1.50). Women in the highest quartile of urinary BPA had a 30% reduction in fecundability (FOR = 0.70, 95% CI: 0.51, 0.96) and a 64% increase in odds of infertilit...Continue Reading

Citations

Mar 11, 2020·Frontiers in Public Health·Meiqin WuChonghuai Yan
Mar 18, 2020·International Journal of Molecular Sciences·Andressa GonsioroskiJodi A Flaws
Jan 24, 2020·Obstetrics & Gynecology Science·Yeon Jean ChoHyun Young Kwon
May 17, 2019·International Journal of Endocrinology·Ewa MatuszczakAdam Hermanowicz
Feb 20, 2020·International Journal of Environmental Research and Public Health·Francisco M PeinadoFrancisco Artacho-Cordón
Jan 11, 2019·International Journal of Epidemiology·Jun ZhangUNKNOWN Shanghai Birth Cohort
Sep 29, 2018·Basic & Clinical Pharmacology & Toxicology·Jerrold J Heindel
Jul 13, 2019·Environmental Research·Ya MaHuizhen Zhang
Apr 12, 2021·Diabetes & Metabolic Syndrome·Iram Ashaq KawaFouzia Rashid
May 6, 2021·International Journal of Molecular Sciences·Mateusz KunyszDorota Darmochwał-Kolarz
Dec 2, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lama IskandaraniBarbara F Hales

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