Associations of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms on fat mass and fat mass distribution in prepubertal obese children.

Journal of Physiology and Biochemistry
Pascal BaratMarie-Pierre Moisan

Abstract

Previous studies conducted in adult obese patients have shown that glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms influence cortisol-driven obesity and metabolic parameters. We investigated the impact of these polymorphisms in prepubertal obese children that were thoroughly examined for hypothalamic-pituitary-adrenal axis activity and for metabolic and obesity parameters. Obese children carrier of the allele G of the BclI polymorphism within glucocorticoid receptor gene tend to present a higher percentage of fat mass as well as a decreased cortisol suppression after low-dose dexamethasone as found in adult studies. Additionally, these allele G carriers show a strong correlation between truncal fat mass distribution and cortisol response to a standardized lunch, whereas this correlation is weak in allele C carriers. No differences were found for obesity or metabolic parameters between genotypes at the corticosteroid-binding globulin locus. However, allele 90 carriers present increased 24-h free urinary cortisol. Overall, this study provides new data showing the influence of glucocorticoid receptor and corticosteroid-binding globulin genes in obesity and/or cortisol action in prepubertal obese chil...Continue Reading

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Citations

Jun 25, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G NoppeE F C van Rossum
Sep 18, 2020·Journal of Applied Physiology·Stephen M RatchfordD Walter Wray
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·C C GeelenB Havekes
Jan 10, 2017·Frontiers in Endocrinology·Marie-Pierre Moisan, Nathalie Castanon
Jan 27, 2021·Journal of Personalized Medicine·Olga I KiselevaElena A Ponomarenko

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