PMID: 9194760Jun 1, 1997Paper

Associations of HDL2 and HDL3 subfractions with ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study

Arteriosclerosis, Thrombosis, and Vascular Biology
B LamarcheJ P Després

Abstract

Individuals with elevated plasma concentrations of HDL cholesterol are at lower risk for ischemic heart disease (IHD). Whether the cardioprotective effects of HDL can be attributed to one or both HDL subfractions (HDL2 and HDL3) remains, however, controversial. The relationship of HDL subfractions to the incidence of IHD was investigated in a sample of 1169 French-Canadian men younger than 60 years and living in the Quebec City suburbs. Between 1980 to 1981 and 1990, 83 of the 944 men with complete follow-up in 1990 (80.8%) had a first IHD. Men who developed IHD had lower HDL, HDL2, and HDL3 cholesterol concentrations at baseline than men who remained free from IHD. Adjusted relative risk (RR) of IHD was calculated among quartiles of HDL cholesterol and HDL subfractions with the use of Cox survival models. Men in the fourth quartile of HDL2 (RR = 0.21; 95% confidence interval [CI], 0.08 to 0.56) and HDL3 cholesterol distributions (RR = 0.37; 95% CI, 0.15 to 0.94) were at lower risk for IHD than men in the first quartile. Despite the fact that the respective contributions of HDL2 and HDL3 to IHD risk were of the same magnitude in a multivariate model that included both subfractions, the contribution of the HDL2 subfraction was s...Continue Reading

References

Aug 8, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Nov 9, 1989·The New England Journal of Medicine·D J Gordon, B M Rifkind
Jul 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D RobinsonD J Galton
Jan 1, 1986·Methods in Enzymology·P S Bachorik, J J Albers
Jun 1, 1985·Metabolism: Clinical and Experimental·P T WilliamsN Ellsworth
Oct 1, 1966·Circulation·J W GofmanR Tandy
Jun 1, 1984·International Journal of Epidemiology·M G Marmot
Jul 1, 1984·American Heart Journal·R F GillumT E Kottke
Sep 28, 1994·JAMA : the Journal of the American Medical Association·P M RidkerC H Hennekens
Jun 1, 1993·The American Journal of Medicine·D I SilvermanR C Pasternak
Oct 1, 1951·The American Journal of Medicine·D P BARRH A EDER

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Citations

Jul 12, 2008·Clinical and Experimental Medicine·Aleksandra ZeljkovicDimitra Kalimanovska-Ostric
Oct 28, 2009·Cardiovascular Drugs and Therapy·Mariann HarangiGyörgy Paragh
Sep 8, 2001·The American Journal of Cardiology·H S Hecht
Feb 19, 2002·Atherosclerosis·Agnès PascotJean Pierre Després
Mar 13, 2002·Atherosclerosis·Dmitri Sviridov, Paul Nestel
Aug 13, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Yohan BosséMarie-Claude Vohl
Aug 21, 2013·International Journal of Endocrinology·Kristina BlaslovLea Duvnjak
Feb 11, 2009·Medicine and Science in Sports and Exercise·Ann J BrownP Laura Svetkey
Aug 3, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Dick C ChanGerald F Watts
Oct 4, 2011·Internal Medicine·Noboru HiratsukaEiko Takahashi
Mar 23, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Mandana RadJacobus Burggraaf
Jul 2, 2014·European Heart Journal·Seth S MartinUNKNOWN Lipoprotein Investigators Collaborative (LIC)
May 27, 2004·Diabetes Care·Ronald M Krauss
Nov 15, 2007·Diabetes Care·Konstantinos KantartzisNorbert Stefan
Jul 27, 2014·European Journal of Preventive Cardiology·Parag H JoshiUNKNOWN Lipoprotein Investigators Collaborative (LIC) Study Group
Oct 26, 2002·The American Journal of Cardiology·Martin I FreedUNKNOWN Rosiglitazone Study 108 investigators
Jul 21, 2004·Endocrinology and Metabolism Clinics of North America·Daniel EinhornRobert R Henry
Jan 1, 2008·Journal of Lipid Research·Bernhard KaessChristian Hengstenberg
Apr 14, 2007·Journal of Lipid Research·Christian SchäferKarl Winkler
Jul 20, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giuliano GenerosoMarcio Sommer Bittencourt
Jul 9, 2009·Obesity·Kirsi H PietiläinenJaakko Kaprio
Mar 13, 2014·Journal of the American Society of Nephrology : JASN·Ian H de Boer, John D Brunzell
Apr 22, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I L RuelUNKNOWN Québec LipD Study

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