Associations of high sensitivity C-reactive protein levels in schizophrenia and comparison groups

Schizophrenia Research
Jamie JosephDilip V Jeste

Abstract

Schizophrenia is characterized by physical (mainly metabolic and cardiovascular) comorbidity and shortened lifespan. High sensitivity C-reactive protein (hs-CRP), an inflammatory marker of hepatic origin linked to metabolic and cardiovascular diseases and mortality in the general population, has been reported to be elevated in people with schizophrenia. However, the relationship of hs-CRP to psychiatric and medical risk factors, after controlling for potentially confounding variables such as smoking, is not well established in schizophrenia. We assessed hs-CRP levels along with various demographic, psychiatric, and metabolic measures in 88 clinically stable outpatients with schizophrenia or schizoaffective disorder and 71 age epoch-matched comparison subjects with no history of a major psychiatric illness. hs-CRP levels were significantly higher in individuals with schizophrenia than in comparison subjects. Higher hs-CRP levels in the schizophrenia group were associated with female gender, more severe negative symptoms, greater medical comorbidity, and worse metabolic risk factors including BMI, fasting glucose, and hemoglobin A1c levels. hs-CRP was not related to age, race, education, smoking status, antipsychotic dosage, or c...Continue Reading

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Citations

May 5, 2016·Schizophrenia Bulletin·Ewa BulzackaUNKNOWN FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) Group
Jun 20, 2016·Schizophrenia Research·Ellen E LeeDilip V Jeste
Apr 28, 2016·Nordic Journal of Psychiatry·Adam WysokińskiTomasz Kostka
Sep 22, 2016·Schizophrenia Research·Suzi HongDilip V Jeste
Nov 12, 2016·Journal of Psychiatric Research·Owen M WolkowitzHelena Kraemer
Nov 12, 2017·European Archives of Psychiatry and Clinical Neuroscience·G FondUNKNOWN FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group
Sep 25, 2017·European Archives of Psychiatry and Clinical Neuroscience·Tanya T NguyenLisa T Eyler
Mar 25, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Abdullah BoluÖzcan Uzun
Aug 13, 2017·Scientific Reports·Parvin KumarCatharina Lavebratt
May 6, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Elżbieta KozłowskaEwa Brzezińska-Błaszczyk
Nov 6, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·L García-ÁlvarezJ Bobes
Oct 20, 2019·Molecular Psychiatry·Keely A MuscatellKathryn L Humphreys
May 9, 2019·Frontiers in Psychiatry·Virawudh SoontornniyomkijDilip V Jeste
Mar 12, 2020·The Psychiatric Quarterly·Rabia Nazik YükselErol Göka
Apr 12, 2019·Journal of Molecular Neuroscience : MN·Afsane BahramiMajid Ghayour-Mobarhan
Sep 8, 2018·Frontiers in Psychiatry·Guillaume FondLaurent Boyer
May 21, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·E J LiemburgH Knegtering
Dec 10, 2020·Neuropsychiatric Disease and Treatment·Li-Hong PanYuzhong Yan
Jan 8, 2019·Psychiatry Research·Elżbieta KozłowskaEwa Brzezińska-Błaszczyk
Oct 16, 2021·Translational Psychiatry·Caitlin E MurphyCynthia Shannon Weickert

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