Abstract
Hypertension (HTN), dyslipidemia and hyperhomocysteinemia (HHcy) are risk factors for cardiovascular disease (CVD). Hypertensive Chinese subjects (n = 228) were enrolled. MTHFR C667T, MTHFR A1298C, MTR A2756G, and MTRR A66G genotypes were determined. Unconditional logistic regression was performed to determine the associations of serum Hcy status and genotypes with HTN and dyslipidemia. The mean age of hypertensive adults was 65.53 ± 9.94 years, including 88 (38.6%) men and 140 (61.4%) women. Patients with MTHFR 667TT and MTRR GG carriers showed higher serum Hcy levels (P = 0.019 and 0.018, respectively), which is associated with higher serum triacylglycerols (TAG) and total cholesterol (TC) levels (P = 0.014 and 0.044, respectively) and a higher risk for hypertriglyceridemia (OR = 1.889, 95% CI: 1.105-3.229, P = 0.020). Compared with low Hcy and MTRR 66AA, those with high Hcy and 66AA or 66AG+GG showed higher odd\s of hypertriglyceridemia (MTRR 66AA+ high Hcy: OR: 2.692, 95% CI: 1.189-6.096, Pcombined = 0.018; MTRR 66AG/GG+ high Hcy: OR: 3.433, 95% CI: 1.517-7.772, Pcombined = 0.003, respectively). Patients with high Hcy and MTHFR 667CC, as well as those with low Hcy and 667CT+TT, showed lower odds of uncontrolled SBP (MTHFR 6...Continue Reading
References
Apr 25, 1991·The New England Journal of Medicine·R ClarkeI Graham
May 1, 1990·The Journal of Nutritional Biochemistry·J D Finkelstein
Sep 9, 2005·Journal of Cellular Biochemistry·Neetu TyagiSuresh C Tyagi
Jan 5, 2006·Annals of Nutrition & Metabolism·Frank HircheKlaus Eder
Mar 3, 2007·Molecular and Cellular Biochemistry·Suchita MarkanMadhu Khullar
Aug 30, 2007·European Journal of Human Genetics : EJHG·Xueqing QianDaru Lu
Jul 26, 2008·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ping-Ting LinYi-Chia Huang
Mar 7, 2009·Biomedical and Environmental Sciences : BES·Lei HuangYong Li
Apr 28, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Govindaiah VinukondaRadha Rama Devi Akella
Aug 6, 2009·European Journal of Clinical Nutrition·L L N HusemoenT Jørgensen
May 7, 2010·Journal of Human Hypertension·S JiangX Xu
Oct 28, 2010·Lipids in Health and Disease·Lin ZhangShang-Ling Pan
Jul 7, 2011·Indian Journal of Clinical Biochemistry : IJCB·Madhumita DasN Choudhury
Oct 20, 2011·Clinical Biochemistry·Yih-Hsin ChangMing-Yuh Shiau
Mar 14, 2012·Orvosi hetilap·Krisztina MarosiZsolt B Nagy
Apr 17, 2012·Gene·Huifeng XuMing Luo
Nov 8, 2012·International Journal of Hypertension·Javed Y FowdarLyn R Griffiths
Nov 29, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shanqun JiangYi-Hsiang Hsu
Sep 5, 2013·Circulation·Samia MoraPaul M Ridker
Jan 25, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Yu WangShanqun Jiang
May 7, 2014·Advances in Medical Sciences·Aleksandra BaszczukGabriela Dopierała
May 14, 2014·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Kamile YücelAli Unlü
Jul 23, 2014·Clinical and Experimental Hypertension : CHE·Huili ChenZheng Wan
Dec 30, 2014·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Anzel BahadırYasin Türker
Aug 8, 2015·Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·Fang ChenMengzhi Yang
Sep 5, 2015·Lipids in Health and Disease·Wen-Xing LiJing-Fei Huang
Oct 1, 2015·Journal of Nutrigenetics and Nutrigenomics·Carla C MoraisCristiane Cominetti
Oct 8, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Yanhong LiuXiping Xu
Jun 19, 2016·Indian Heart Journal·Jyotdeep K RainaParvinder Kumar
Dec 3, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Liyuan HanShiwei Duan
Dec 16, 2016·Minerva medica·Zhi TangTao Zhang
Apr 4, 2017·International Journal of Environmental Research and Public Health·Ye ChangYingxian Sun
Apr 12, 2017·Clinical Laboratory·Wen-Xing LiFang Liu
Jul 26, 2017·Scientific Reports·Mohetaboer MominYong Huo
Sep 20, 2017·Lipids in Health and Disease·Mina ZarinviarsaghHossein Sadeghi
Oct 11, 2017·American Journal of Hypertension·Yi-Fei DongXiao-Shu Cheng
Dec 6, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Suhua LiJinlai Liu