Associations of human gene EPB41L3 DNA methylation and cervical intraepithelial neoplasia in women living with HIV-1 in Africa

AIDS
Helen KellyAttila Lörincz

Abstract

To evaluate associations of DNA methylation of the human tumour suppressor gene EPB41L3 with high-grade cervical intraepithelial neoplasia (CIN2+) and HIV-related factors among women living with HIV-1 (WLHIV) in Burkina Faso and South Africa. Case-control study of WLHIV aged 25-50 with histology-determined CIN2+ (cases, N = 152) and ≤CIN1 (controls, N = 210). EPB41L3 methylation was measured by pyrosequencing of bisulphite converted DNA from exfoliated cervical specimens at baseline and 16 months later. Median methylation levels were compared across CIN grades using the Mann-Whitney test and Cuzick test for trend. EPB41L3 methylation levels were dichotomized into 'high' and 'low' using the 66.7 percentile point of the distribution in the controls. Associations of EPB41L3 methylation with HIV-related factors were estimated by logistic regression. Among 94 WLHIV in Burkina Faso and 268 in South Africa, median methylation levels at baseline for EPB41L3 increased with increasing CIN grade in both countries (P-trend <0.001).'High' methylation was more frequent among women with a longer time since HIV diagnosis in Burkina Faso [>5 years vs. ≤5 years; adjusted odds ratio (aOR) = 4.15, 95% CI 1.09-15.83, adjusted for age, CD4 count, hi...Continue Reading

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Citations

Jul 26, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karolina LouvantoAttila Lorincz
Sep 24, 2019·International Journal of Oncology·Xiaofeng YuanZhiwei Liu
Apr 7, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wieke W KremerChris J L M Meijer
Jun 25, 2020·Clinical Epigenetics·Linghua KongLei Li
Oct 27, 2018·International Journal of Molecular Sciences·Wieke W KremerChris J L M Meijer
May 25, 2021·Frontiers in Immunology·Ravesh SinghThumbi Ndung'u

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