Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers.

Journal of Lipid Research
Aruna GorusupudiPaul S Bernstein

Abstract

The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of donor eyes and related their retinal lipid profiles with systemic biomarkers of lipid intake. We found that serum and red blood cell lipids, and to a lesser extent orbital fat, are indeed excellent biomarkers of retinal lipid content and n-3/n-6 ratios in both the LC-PUFA and VLC-PUFA series. Eyes from age-related macular degeneration (AMD) donors have significantly decreased levels of VLC-PUFAs and low n-3/n-6 ratios. These results are consistent with the protective role of dietary n-3 LC-PUFAs against AMD and emphasize the importance of monitoring systemic biomarkers of lipid intake when undertaking clinical trials of lipid supplements for prevention and treatment of retinal disease.

References

Jan 1, 1983·Progress in Lipid Research·S J Fliesler, R E Anderson
Aug 1, 1994·The American Journal of Clinical Nutrition·M MakridesR A Gibson
Feb 7, 2001·The American Journal of Clinical Nutrition·E ChoS E Hankinson
Feb 15, 2001·Nature Genetics·X ZhangY Shen
Aug 14, 2001·Archives of Ophthalmology·J M SeddonW Willett
Jan 23, 2002·Ophthalmic Genetics·R AyyagariR Allikmets
Sep 27, 2002·The American Journal of Clinical Nutrition·Ana BaylinHannia Campos
Apr 16, 2003·Archives of Ophthalmology·Redmer van LeeuwenPaulus T V M de Jong
Jan 2, 2004·The New England Journal of Medicine·James H DwyerMargarete Mehrabian
Nov 24, 2004·Progress in Retinal and Eye Research·John Paul SanGiovanni, Emily Y Chew
Jan 13, 2006·Current Opinion in Lipidology·Ana Baylin, Hannia Campos
Jan 11, 2007·Archives of Ophthalmology·Margaret M DeAngelisThaddeus P Dryja
May 16, 2007·Archives of Ophthalmology·John Paul SanGiovanniUNKNOWN Age-Related Eye Disease Study Research Group
Jan 17, 2008·Progress in Lipid Research·Gerd Schmitz, Josef Ecker
Aug 12, 2009·The British Journal of Ophthalmology·Anne McMahon, Wojciech Kedzierski
Mar 20, 2010·Journal of Lipid Research·Martin-Paul AgbagaRobert E Anderson
Dec 27, 2011·The Journal of Biological Chemistry·Richard HarkewiczKang Zhang
May 10, 2012·Journal of Nutrition and Metabolism·E PattersonC Stanton
Sep 6, 2012·Molecular Medicine Reports·Junhui YiQingjiong Zhang
Feb 12, 2013·Ophthalmology·Eric H SouiedUNKNOWN Nutritional AMD Treatment 2 Study Group
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Peter BarabasDavid Križaj
May 7, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN Age-Related Eye Disease Study 2 Research Group
Feb 22, 2014·Investigative Ophthalmology & Visual Science·Bénédicte M J MerleUNKNOWN Nutritional AMD Treatment 2 Study Group
Mar 26, 2014·Advances in Experimental Medicine and Biology·Martin-Paul AgbagaRobert E Anderson
May 17, 2014·Investigative Ophthalmology & Visual Science·Martin-Paul AgbagaOrson L Moritz
Mar 5, 2015·Nature Communications·Dennis S RiceNicolas G Bazan

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Citations

Oct 3, 2018·British Journal of Pharmacology·Khaled ElmasryMohamed Al-Shabrawey
May 21, 2019·Molecular Nutrition & Food Research·Aruna GorusupudiPaul S Bernstein
Apr 3, 2020·Biological & Pharmaceutical Bulletin·Ryosuke Fukuda, Tatsuya Murakami
Jun 17, 2020·Nature Biotechnology·Hiroshi TsugawaMakoto Arita
Oct 18, 2020·Nutrients·Veronica A MullinsFloyd H Chilton
Feb 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Aruna GorusupudiPaul S Bernstein
Feb 9, 2021·Journal of Lipid Research·Gyening Kofi YeboahMartin-Paul Agbaga
Jun 4, 2021·Organic & Biomolecular Chemistry·Alexander WadeJon D Rainier
Jul 30, 2021·Clinical and Translational Medicine·Niyazi AcarUNKNOWN Biomarkers of Lipid Status And metabolism in Retinal ageing (BLISAR) Study Group
Aug 15, 2021·The Science of the Total Environment·Elin SørhusKai K Lie

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