Abstract
Cardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids. Muscle biopsies were performed on the vastus lateralis in 16 subjects (BMI = 27.62 ± 4.71 kg/m2, age = 32.24 ± 6.37 years, 43% African American). The distribution of type I, IIa, and IIx myofibers was determined via immunohistochemistry performed on frozen cross-sections. Pearson correlation analyses were performed to assess associations between myofiber composition, SI, arterial elasticity, blood pressure, and blood lipid concentrations. The percentage of type I myofibers positively correlated with SI and ne...Continue Reading
References
Apr 1, 1979·Clinical Science·A Juhlin-DannfeltP Tesch
Apr 1, 1992·Journal of Applied Physiology·T P MartinD C Reid
Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·L C GroopR A DeFronzo
Jun 1, 1991·Hypertension·A P Rocchini
Feb 1, 1990·Metabolism: Clinical and Experimental·T PollareC Berne
Oct 25, 1986·Lancet·M J MartinD Wentworth
Nov 1, 1986·Journal of Applied Physiology·P F AmaC Bouchard
Dec 1, 1988·Diabetes·G M Reaven
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Aug 1, 1987·The Journal of Clinical Investigation·S LilliojaC Bogardus
Jan 1, 1983·Acta Medica Scandinavica·M Frisk-HolmbergL Wibell
Sep 1, 1995·Hypertension·J N CohnJ Mock
Jan 1, 1996·Free Radical Biology & Medicine·J A Berliner, J W Heinecke
Oct 1, 1996·Diabetologia·J R ZierathH Wallberg-Henriksson
Jul 1, 1997·Annals of Human Biology·W J DueyR Trudell
Jan 14, 1999·Journal of Applied Physiology·M J CastroG A Dudley
May 25, 2004·Journal of Applied Physiology·Marcas M BammanRichard M Allman
Oct 16, 2004·PLoS Biology·Juleen R Zierath, John A Hawley
Jul 30, 2005·Journal of Applied Physiology·Jeong-su KimMarcas M Bamman
Mar 29, 2006·Diabetes Care·Andreas OberbachKarla Punkt
Nov 2, 2006·Scandinavian Journal of Medicine & Science in Sports·M RönnbackH Tikkanen
Nov 18, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S A Ritchie, J M C Connell
Mar 3, 2007·Circulation Research·Nageswara R Madamanchi, Marschall S Runge
Jun 18, 2010·Atherosclerosis·Masayuki OchiTetsuro Miki
Mar 9, 2011·Acta Physiologica·J Nielsen, D L Christensen
Jul 15, 2011·Diabetes Research and Clinical Practice·Tae Nyun KimKyung Mook Choi
Aug 24, 2011·Hypertension·Bas C van BusselCoen D Stehouwer
Nov 18, 2011·International Journal of Sport Nutrition and Exercise Metabolism·John QuindryZea Urbiztondo
Jul 7, 2012·European Journal of Applied Physiology·Jeremy P LoennekeMichael G Bemben
Mar 22, 2013·The Journal of Clinical Endocrinology and Metabolism·Charles A StuartMichael H Stone
Jun 15, 2013·Journal of Applied Physiology·Ceren Yarar-FisherMarcas M Bamman
Jun 22, 2013·Journal of Diabetes·Chih-Chun ChangLi-Man Hung
May 20, 2014·Archives of Gerontology and Geriatrics·Seung Won LeeHyeon Chang Kim
Sep 5, 2014·Diabetes·Peter H AlbersJørgen F P Wojtaszewski
Dec 6, 2014·Topics in Spinal Cord Injury Rehabilitation·Yaga SzlachcicJames S Krause
Jul 18, 2015·Journal of Applied Physiology·M Harold LaughlinJ Wade Davis
Oct 20, 2015·Progress in Molecular Biology and Translational Science·T Dylan OlverM Harold Laughlin
Citations
Jan 31, 2020·Journal of Cachexia, Sarcopenia and Muscle·Jean-Christophe LagacéIsabelle J Dionne
Feb 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan XiongShihuan Kuang
Oct 2, 2020·GeroScience·Richard KirwanClaire Stewart
Apr 9, 2019·Journal of Obesity·Gary R HunterGordon Fisher
Jan 9, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yoichi NozatoHiromi Rakugi
Dec 28, 2019·The American Journal of Clinical Nutrition·Jeannie TayBarbara A Gower
Sep 22, 2018·Journal of Strength and Conditioning Research·Gary R HunterStephen J Carter
Dec 19, 2020·Frontiers in Nutrition·Paul T MorganLeigh Breen
Oct 21, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·René MaréchalMartin Brochu
Jun 3, 2021·Nutrients·Dejan ReljicYurdagül Zopf
Sep 7, 2021·Frontiers in Physiology·Cory T RichardsRachel N Lord
Sep 26, 2021·Experimental Gerontology·Georgia Colleluori, Dennis T Villareal
Oct 5, 2021·Physiological Reports·Gordon FisherBarbara A Gower
Dec 4, 2021·Scientific Reports·Louise Y TakeshitaFrancesco Falciani