Associations of human skeletal muscle fiber type and insulin sensitivity, blood lipids, and vascular hemodynamics in a cohort of premenopausal women

European Journal of Applied Physiology
Gordon FisherGary R Hunter

Abstract

Cardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids. Muscle biopsies were performed on the vastus lateralis in 16 subjects (BMI = 27.62 ± 4.71 kg/m2, age = 32.24 ± 6.37 years, 43% African American). The distribution of type I, IIa, and IIx myofibers was determined via immunohistochemistry performed on frozen cross-sections. Pearson correlation analyses were performed to assess associations between myofiber composition, SI, arterial elasticity, blood pressure, and blood lipid concentrations. The percentage of type I myofibers positively correlated with SI and ne...Continue Reading

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Citations

Jan 31, 2020·Journal of Cachexia, Sarcopenia and Muscle·Jean-Christophe LagacéIsabelle J Dionne
Feb 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan XiongShihuan Kuang
Apr 9, 2019·Journal of Obesity·Gary R HunterGordon Fisher
Jan 9, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yoichi NozatoHiromi Rakugi
Dec 28, 2019·The American Journal of Clinical Nutrition·Jeannie TayBarbara A Gower
Sep 22, 2018·Journal of Strength and Conditioning Research·Gary R HunterStephen J Carter
Dec 19, 2020·Frontiers in Nutrition·Paul T MorganLeigh Breen
Oct 21, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·René MaréchalMartin Brochu
Sep 26, 2021·Experimental Gerontology·Georgia Colleluori, Dennis T Villareal
Oct 5, 2021·Physiological Reports·Gordon FisherBarbara A Gower

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Methods Mentioned

BETA
X-ray
biopsy
biopsies

Software Mentioned

Statistical Package for the Social Sciences ( SPSS
ADULT
LUNAR
- DPX L

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