Associations of hyperosmolar medications administered via nasogastric or nasoduodenal tubes and feeding adequacy, food intolerance and gastrointestinal complications amongst critically ill patients: A retrospective study

Clinical Nutrition ESPEN
Evertine WesselinkArthur R H van Zanten

Abstract

Adequate nutrition is essential during critical illness. However, providing adequate nutrition is often hindered by gastro-intestinal complications, including feeding intolerance. It is suggested that hyperosmolar medications could be causally involved in the development of gastro-intestinal complications. The aims of the present study were 1) to determine the osmolality of common enterally administered dissolved medications and 2) to study the associations between nasogastric and nasoduodenal administered hyperosmolar medications and nutritional adequacy as well as food intolerance and gastro-intestinal symptoms. This retrospective observational cohort study was performed in a medical-surgical ICU in the Netherlands. Adult critically ill patients receiving enteral nutrition and admitted for a minimum ICU duration of 7 days were eligible. The osmolalities of commonly used enterally administrated medications were measured using an osmometer. Patients were divided in two groups: Use of hyperosmolar medications (>500 mOsm/kg) on at least one day during the first week versus none. The associations between the use of hyperosmolar medications and nutritional adequacy were assessed using multiple logistic regression analysis. The asso...Continue Reading

Citations

Jul 28, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Zeinab JavidAbdolreza Norouzy
May 6, 2021·BMC Pediatrics·Ying ZhouWeibing Tang
May 25, 2021·Clinical Nutrition ESPEN·Iván Osuna-PadillaSebastián Rodríguez-Llamazares

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