Abstract
Asthma is an inflammatory disorder of the airways and the symptoms of asthma could be exacerbated by Mycoplasma pneumoniae infection. Interleukin-2 and interleukin-4 have been implicated in immune and inflammatory reactions. We examined the associations of IL2 and IL4 polymorphisms and expression with the risks of asthma and M. pneumoniae infection in children. 392 asthmatic children and 849 controls were recruited into the study. Eight polymorphisms in IL2 and IL4 were genotyped with Sequenom MassARRAY platform. M. pneumoniae infection and copy number was determined with fluorescence PCR. IL-2 and IL-4 serum expression levels were determined by using ELISA. We found a significant association of IL2 rs6534349 polymorphism with increased asthma risk (heterozygotes, P=.029; homozygous variants; P=.013) and of IL4 rs2227284 polymorphism with reduced asthma risk (heterozygotes, P=.026; homozygous variants; P=.001). Besides, the association of other polymorphisms, except rs2070874 polymorphism, became apparent when the asthmatic children were grouped according to GINA classification of asthma control and severity. In addition, IL-2 and IL-4 serum expression levels were significantly higher in M. pneumoniae negative (P=.038) and posi...Continue Reading
References
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·E NoguchiH Hamaguchi
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra BiscardiDominique Gendrel
Oct 19, 2004·Clinical Microbiology Reviews·Ken B Waites, Deborah F Talkington
Mar 29, 2006·Current Allergy and Asthma Reports·Gerard H Koppelman
Feb 20, 2007·Postgraduate Medical Journal·Nazima NisarNihar Ranjan Biswas
May 12, 2007·Brain, Behavior, and Immunity·Edith Chen, Gregory E Miller
May 16, 2009·The Journal of Allergy and Clinical Immunology·Sheila J BartonIan Sayers
Feb 27, 2010·BMC Infectious Diseases·Anna C NilssonKenneth Persson
Feb 15, 2011·Biomedical and Environmental Sciences : BES·Juan BaiRong-Wei Ye
Jul 25, 2012·Vaccine·Yangyang WangYi-Hua Zhou
Apr 30, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Pamela R WoodEdward G Brooks
Jun 29, 2013·Cancer Epidemiology·Mohd Shafi'i Mohd SuzairiRavindran Ankathil
Sep 3, 2013·Medical Oncology·Shing Cheng TanRavindran Ankathil
Citations
May 6, 2020·Diagnostics·Enrique Ambrocio-OrtizRamcés Falfán-Valencia
Nov 25, 2020·BMC Medical Genetics·Danyal ImaniRamazan Rezaei
Oct 23, 2020·BMC Immunology·Ahmad KoushaHaleh Mikaeili
May 2, 2021·Microbial Pathogenesis·Xiaoran LiuKun Liu