Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study

BMC Endocrine Disorders
Aurelian BidulescuAdolfo Correa

Abstract

Growing evidence suggests that leptin is critical for glycemic control. Impaired leptin signaling may also contribute to low adiponectin expression in obese individuals. We assessed the association of leptin and adiponectin with incident type 2 diabetes (T2D), their interactions with sex and obesity status, and mediation by insulin resistance. We included study participants from the Jackson Heart Study, a prospective cohort of adult African Americans in Jackson, Mississippi, that were free of T2D at the baseline Exam 1. Incident T2D was defined as new cases at Exam 2 or Exam 3. We created separate Cox regression models (hazard ratios per log-transformed ng/mL of leptin and adiponectin) with and without insulin resistance, HOMA-IR. Mediation by insulin resistance was analyzed. Several interactions were assessed, including by sex, HbA1c, and obesity. Among our 3363 participants (mean age 53 years, 63% women), 584 developed incident T2D. Leptin was directly associated with incident T2D when modeled without HOMA-IR (HR = 1.29, 95% CI = 1.05-1.58). This direct association between leptin and T2D was significant among men (HR = 1.33, 95% CI = 1.05-1.69), but nonsignificant among women (HR = 1.24, 95% CI = 0.94-1.64); statistical inter...Continue Reading

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Citations

Nov 26, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·Arnaud D KazeJustin B Echouffo-Tcheugui
Feb 13, 2021·Journal of the American College of Cardiology·Nikolaos PerakakisChristos S Mantzoros
Feb 13, 2021·Vaccines·Jorge Pérez-GalarzaLucy Baldeón
Apr 14, 2021·Current Diabetes Reports·Cassandra N Spracklen, Xueling Sim

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