Associations of lncRNA H19 Polymorphisms at MicroRNA Binding Sites with Glioma Susceptibility and Prognosis

Molecular Therapy. Nucleic Acids
Yujiao DengZhijun Dai

Abstract

Glioma is the most common tumor of the central nervous system; variation in susceptibility and prognosis worldwide suggests that there are molecular and genetic differences among individuals. The H19 gene plays a dual role in carcinogenesis. In this study, associations between H19 polymorphisms and susceptibility as well as prognosis in glioma were evaluated. In total, 605 patients with glioma and 1,300 cancer-free subjects were enrolled in the study. Individuals with the rs3741219 A>G allele were less likely to develop glioma (relative risk [RR] = 0.54, 95% confidence interval [95% CI] = 0.45-0.63, p < 0.001), whereas rs217727 G>A and rs2839698 G>A genotypes were not associated with glioma risk. The associations between H19 polymorphisms and prognosis were assessed, including overall survival and progression-free survival. Three focused H19 polymorphisms did not show a significant effect on survival. Further analysis based on false-positive report probability validated these significant results. In the haplotype analysis, individuals with the Grs217727Ars2839698Grs3741219 haplotype were less likely to develop glioma (odds ratio [OR] = 0.33, 95% CI = 0.23-0.46, p = 0.02). Overall, carriers of the rs3741219 AG or GG genotype of ...Continue Reading

Citations

May 21, 2020·Cancers·Lysann Tietze, Sonja M Kessler
Jan 26, 2021·Pharmacogenomics and Personalized Medicine·Zhaoshi ZhengSongyan Liu
Apr 1, 2021·Medicine·Shipei WangLiang Guo
Sep 2, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Huiqin GuoZhenjian Zhuo

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Methods Mentioned

BETA
histone acetylation
genotyping

Software Mentioned

SNPinfo
R

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