Associations of Long-Term Exposure to Ultrafine Particles and Nitrogen Dioxide With Increased Incidence of Congestive Heart Failure and Acute Myocardial Infarction

American Journal of Epidemiology
Li BaiHong Chen

Abstract

Although long-term exposure to traffic-related air pollutants such as nitrogen dioxide has been linked to cardiovascular disease (CVD) mortality, little is known about the association between ultrafine particles (UFPs), defined as particles less than or equal to 0.1 μm in diameter, and incidence of major CVD events. We conducted a population-based cohort study to assess the associations of chronic exposure to UFPs and nitrogen dioxide with incident congestive heart failure (CHF) and acute myocardial infarction. Our study population comprised all long-term Canadian residents aged 30-100 years who lived in Toronto, Ontario, Canada, during the years 1996-2012. We estimated annual concentrations of UFPs and nitrogen dioxide by means of land-use regression models and assigned these estimates to participants' postal-code addresses in each year during the follow-up period. We estimated hazard ratios for the associations of UFPs and nitrogen dioxide with incident CVD using random-effects Cox proportional hazards models. We controlled for smoking and obesity using an indirect adjustment method. Our cohorts comprised approximately 1.1 million individuals at baseline. In single-pollutant models, each interquartile-range increase in UFP ex...Continue Reading

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Citations

Jul 16, 2019·International Journal of Cancer. Journal International Du Cancer·Li BaiHong Chen
May 7, 2019·American Journal of Respiratory and Critical Care Medicine·Jenny A BossonThomas Sandström
Mar 24, 2020·Experimental & Molecular Medicine·Dean E Schraufnagel
May 23, 2020·Environmental Health Perspectives·Johannah CramerZorana J Andersen
Nov 6, 2020·Circulation·Joel D KaufmanUNKNOWN American Heart Association Advocacy Coordinating Committee
Feb 6, 2021·Environmental Science & Technology·Elena AustinEdmund Seto
Dec 4, 2019·The Science of the Total Environment·Rena R JonesDebra T Silverman
Oct 7, 2021·Journal of the American Heart Association·Youn-Hee LimZorana J Andersen

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