Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations.

JAMA Pediatrics
Bradley S PetersonRavi Bansal

Abstract

Increasing rates of illicit drug use during pregnancy may be associated with risk for long-term health problems in prenatally exposed children. To identify the associations of prenatal exposure to illicit drugs with organization of the newborn brain. For this cohort study, a volunteer sample of 210 illicit drug-using and nonusing mothers and their newborns was enrolled from prenatal clinics and drug abuse treatment programs in New York, New York. Enrollment, scanning, and long-term follow-up occurred from September 2004 through February 2012, and image processing and statistical analyses continued through fall 2018. In addition to 26 participants with incomplete data, a total of 64 mothers were lost to follow-up during pregnancy, and 13 newborns were lost to follow-up at birth because of perinatal complications. Newborns were assigned to 1 of 4 primary exposure groups based on the history of most frequent maternal drug use: marijuana, cocaine, methadone maintenance, and/or heroin. Unexposed newborns were controls. Unsedated magnetic resonance imaging (MRI) of newborn brains was performed shortly after birth. Infant neurodevelopmental outcomes were assessed at age 12 months. MRI modalities included anatomical imaging, diffusion ...Continue Reading

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Citations

Feb 19, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·James P BoardmanLori A Devlin
Jul 29, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rui ZhangNora D Volkow
Aug 14, 2021·Developmental Cognitive Neuroscience·Moriah E ThomasonChristopher J Trentacosta
Aug 4, 2021·Alcoholism, Clinical and Experimental Research·Fleur L WartonErnesta M Meintjes

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