Associations of measures of systemic blood flow used in a randomized trial of delayed cord clamping in preterm infants

Pediatric Research
Himanshu PopatDavid A Osborn

Abstract

To determine associations of low superior vena cava (SVC) flow (≤55 ml/kg/min) and low right ventricular output (RVO) (≤150 ml/kg/min) in preterm infants. An observational study in infants <30 weeks gestation randomized to receive immediate (<10 s) or delayed cord clamping (DCC) (≥60 s). The study enrolled 265 infants with a mean (SD) gestation 28 (2) weeks. Eighty-six (33%) infants had low SVC flow and 81 (31%) infants had low RVO. In multivariate analysis, low SVC flow was associated with gestation; low RVO was associated with DCC, gender and 5-minute Apgar; whereas mean RVO was negatively associated with both FiO2 and mean airway pressure (MAP) at 9 h and 24 h. Low SVC flow was associated with ductus arteriosus (DA) treatment. Infants with low RVO had higher mortality on univariate analysis, but this was not significant after adjusting for gestation. SVC flow was associated with gestation, whilst RVO was associated with placental transfusion, gender, condition at birth, and early respiratory adaptation. Compared to infants with normal values, more infants with low SVC flow were treated for DA, but infants with low RVO had no significant difference in mortality or morbidity.

References

Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Evans, M Kluckow
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Kluckow, N Evans
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Kluckow, N Evans
Aug 7, 2001·The Journal of Pediatrics·M Kluckow, N Evans
Feb 28, 2002·The Journal of Pediatrics·David OsbornMartin Kluckow
Sep 27, 2003·Seminars in Perinatology·Avroy A FanaroffMichele C Walsh
Nov 7, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·D A OsbornM Kluckow
Nov 3, 2004·The Journal of Pediatrics·Rod W HuntMartin Kluckow
Dec 20, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·J Miletin, E M Dempsey
Sep 27, 2008·European Journal of Pediatrics·J MiletinE M Dempsey
Nov 26, 2008·The Journal of Pediatrics·Beau BattonMichele Walsh
May 20, 2015·Anesthesia and Analgesia·Hannah C GlassPeter J Davis
Jun 27, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sarah BatesAxel Heep
Oct 30, 2016·The Journal of Pediatrics·Himanshu PopatDavid Osborn
Oct 31, 2017·The New England Journal of Medicine·William Tarnow-MordiUNKNOWN Australian Placental Transfusion Study Collaborative Group
Nov 4, 2017·American Journal of Obstetrics and Gynecology·Michael FogartyWilliam Tarnow-Mordi

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Citations

Feb 26, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Eugene M DempseyUNKNOWN HIP consortium

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