Associations of meningioma molecular subgroup and tumor recurrence.

Neuro-oncology
Mark W YoungbloodJennifer Moliterno

Abstract

We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications of this classification for clinical prognostication remain unclear. Integrated genomic and epigenomic analyses implicate unique oncogenic processes associated with each subgroup, suggesting the potential for divergent clinical courses. The aim of this study was to understand the associated clinical outcomes of each subgroup, as this could optimize treatment for patients. We analyzed outcome data for 469 meningiomas of known molecular subgroup, including extent of resection, postoperative radiation, surveillance imaging, and time to recurrence, when applicable. Statistical relationships between outcome variables and subgroup were assessed. Features previously associated with recurrence were further investigated after stratification by subgroup. We used Kaplan-Meier analyses to compare progression-free survival, and identified factors significantly associated with recurrence using Cox proportional hazards modeling. Meningioma molecular subgroups exhibited divergent clinical courses at 2 years of follow-up, with several aggressive subgroups (NF2, PI3K, HH, tumor necrosis factor receptor-associated factor 7 [TRAF7]) recurr...Continue Reading

References

Jan 1, 1989·Acta neurochirurgica·P K GuptaB S Das
Jan 1, 1985·Journal of Neurosurgery·R O MirimanoffR L Martuza
Apr 1, 1994·Genes, Chromosomes & Cancer·M J BelloJ A Rey
Nov 22, 2011·Carcinogenesis·Yugo KishidaToshihiko Wakabayashi
Jan 22, 2013·Nature Genetics·Priscilla K BrastianosRameen Beroukhim
Nov 23, 2013·Brain Pathology·Stéphane GoutagnyMichel Kalamarides
Dec 17, 2015·Journal of the National Cancer Institute·Felix SahmAndreas von Deimling
Jan 31, 2016·Neuro-oncology·Malak AbedalthagafiSandro Santagata
Apr 23, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sayaka YuzawaShinya Tanaka
Aug 23, 2016·Nature Genetics·Victoria E ClarkMurat Günel
Nov 26, 2016·Journal of Neurosurgery·Matthew R StricklandFred G Barker
Feb 15, 2017·Nature Communications·Akdes Serin HarmancıMurat Günel
Aug 1, 2017·Chinese Clinical Oncology·Samuel E Day, Lia M Halasz
Jul 17, 2018·Neuro-oncology·Sabine Spiegl-KreineckerWalter Berger
Aug 21, 2018·Acta Neuropathologica·Tareq A JuratliPriscilla K Brastianos
May 10, 2019·Acta Neuropathologica·Nagarajan ParamasivamFelix Sahm

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