Associations of mid-pregnancy HbA1c with gestational diabetes and risk of adverse pregnancy outcomes in high-risk Taiwanese women

PloS One
Yi-Ran HoYuan-Horng Yan

Abstract

The objective of this study was to investigate the associations among the mid-pregnancy glycated hemoglobin A1c (HbA1c) level, gestational diabetes (GDM), and risk of adverse pregnancy outcomes in women without overt diabetes and with positive 50-g, 1-h glucose challenge test (GCT) results (140 mg/dL or greater). This prospective study enrolled 1,989 pregnant Taiwanese women. A two-step approach, including a 50-g, 1-h GCT and 100-g, 3-h oral glucose tolerance test (OGTT), was employed for the diagnosis of GDM at weeks 23-32. The mid-pregnancy HbA1c level was measured at the time the OGTT was performed. A receiver operating characteristic (ROC) curve was used to determine the relationship between the mid-pregnancy HbA1c level and GDM. Multiple logistic regression models were implemented to assess the relationships between the mid-pregnancy HbA1c level and adverse pregnancy outcomes. An ROC curve demonstrated that the optimal mid-pregnancy HbA1c cut-off point to predict GDM, as diagnosed by the Carpenter-Coustan criteria using a two-step approach, was 5.7%. The area under the ROC curve of the mid-pregnancy HbA1c level for GDM was 0.70. Compared with the levels of 4.5-4.9%, higher mid-pregnancy HbA1c levels (5.0-5.4, 5.5-5.9, 6.0-...Continue Reading

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Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Mar 21, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Paula B RenzJoíza L Camargo
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association
Jun 5, 2020·Archives of Gynecology and Obstetrics·Jana UrbanováJan Brož
Dec 11, 2020·Diabetes Care·UNKNOWN American Diabetes Association
Jul 9, 2021·International Journal of General Medicine·Lihua ZhangDongmei Man
Jul 1, 2021·Obstetrical & Gynecological Survey·Ioannis TsakiridisThemistoklis Dagklis
Aug 11, 2021·JAMA : the Journal of the American Medical Association·Jennifer PillayLisa Hartling
Dec 30, 2021·Diabetes Care·UNKNOWN American Diabetes Association Professional Practice CommitteeMikhail Kosiborod

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