Associations of Musculoskeletal Pain With Mobility in Older Adults: Potential Cerebral Mechanisms

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Yenisel Cruz-AlmeidaHealth ABC Study

Abstract

Musculoskeletal pain is highly prevalent and limits mobility in older adults. A potential mechanism by which pain affects mobility could be through its negative impact on the brain. We examined whether structural integrity of cerebral gray and white matter (WM) mediated the relationship between pain and mobility in community-dwelling older adults. Musculoskeletal pain, gait speed, and neuroimaging data were obtained concurrently from the Health ABC study (mean age = 83/56% female, n = 212). Microstructural gray matter integrity was measured by mean diffusivity (MD), WM microstructure and macrostructure were measured by fractional anisotropy (FA) and WM hyperintensities (WMH), respectively. Regression models were adjusted for gray matter atrophy, age, gender, medication use, and obesity. Bootstrapped mediation methods were used (1,000 bootstrapped samples, 95% confidence intervals). The associations of musculoskeletal pain with WMH (β = .19, p < .05) and FA (β = -.18, p < .05) were robust to adjustment for gender, medication use, age, body mass index (BMI), and brain atrophy. Participants who experienced both knee and back pain had a significantly slower gait speed (~0.11 m/s) than those without knee or back pain (p < .05) indep...Continue Reading

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Citations

Dec 14, 2019·Research in Gerontological Nursing·Staja Q BookerRoger B Fillingim
Dec 18, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Christine MiaskowskiChristine Ritchie
Jan 11, 2020·Frontiers in Aging Neuroscience·Désirée LussierNatalie C Ebner
Sep 29, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Saliu BalogunGraeme Jones
Jan 10, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Erica FigginsManuel Montero-Odasso

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