Associations of Oral α-, β-, and γ-Human Papillomavirus Types With Risk of Incident Head and Neck Cancer

JAMA Oncology
Ilir AgalliuRobert D Burk

Abstract

Prospective studies are needed to examine the temporal relationship between oral human papillomavirus (HPV) detection and risk of head and neck squamous cell carcinoma (HNSCC). Moreover, the oral cavity contains a wide spectrum of α-, β-, and γ-HPV types, but their association with risk of HNSCC is unknown. To prospectively examine associations between α-, β-, and γ-HPV detection in the oral cavity and incident HNSCC. A nested case-control study was carried out among 96 650 participants, cancer free at baseline, with available mouthwash samples in 2 prospective cohort studies: (1) the American Cancer Society Cancer Prevention Study II Nutrition Cohort and (2) the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Incident cases of HNSCC (n = 132) were identified during an average 3.9 years of follow-up in both cohorts. Three controls per case (n = 396) were selected through incidence density sampling and matched on age, sex, race/ethnicity, and time since mouthwash collection. Through a next-generation sequencing assay, DNA from α-, β-, and γ-HPV types were detected. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% CIs, adjusting for smoking history, alcohol consumption, and de...Continue Reading

Citations

May 11, 2016·Virology·Emily Montosa NunesUNKNOWN HIM Study group
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marta Félez-SánchezUNKNOWN VVAPO/RIS HPV TT study groups
Apr 1, 2018·International Journal of Cancer. Journal International Du Cancer·Clorinda AnnunziataMaria Lina Tornesello
Dec 16, 2016·Journal of Clinical Microbiology·Tengguo LiMangalathu S Rajeevan
Nov 6, 2018·The Journal of Infectious Diseases·Rachel L WinerMassimo Tommasino
Dec 6, 2019·Sexually Transmitted Diseases·Helen C Stankiewicz KaritaAnna Wald
Mar 27, 2020·The Journal of Infectious Diseases·Babatunde Y AlliNicolas F Schlecht
Oct 5, 2019·International Journal of Cancer. Journal International Du Cancer·Sreenath MadathilBelinda Nicolau
May 8, 2020·JAMA Otolaryngology-- Head & Neck Surgery·Andrew T DayErich M Sturgis
Jul 28, 2020·Cancer Science·Kai D TangChamindie Punyadeera
Mar 10, 2017·Expert Review of Molecular Diagnostics·Ana Gradíssimo, Robert D Burk
Aug 30, 2018·Nature Communications·Song WuYusuf A Hannun
Jul 17, 2020·MSphere·Lucia MinoniMassimo Tommasino
Apr 27, 2017·Frontiers in Public Health·Katri AroMichael Tu
Sep 27, 2019·Frontiers in Oncology·Panagiota EconomopoulouAmanda Psyrri
Jan 4, 2020·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Gaye KeserFiliz Namdar Pekiner
May 27, 2017·The Journal of Infectious Diseases·Shalaka S HamprasMassimo Tommasino
Feb 8, 2019·Scientific Reports·Jennifer RosenbaumRobert D Burk
May 28, 2019·Frontiers in Oncology·Tarik Gheit
Apr 27, 2019·Frontiers in Cell and Developmental Biology·Madison CanningYan Cui
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·María Guadalupe Flores-MiramontesAdriana Aguilar-Lemarroy
Oct 14, 2020·Reviews in Medical Virology·Rohit GuptaStephen K Tyring
Apr 6, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Laura SicheroUNKNOWN Ludwig-McGill Cohort Study

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.