Associations of pre-diagnostic body mass index with overall and cancer-specific mortality in a large Austrian cohort

Cancer Causes & Control : CCC
Katharina ReichleGabriele Nagel

Abstract

Although obesity is a well-known risk factor for several cancers, its role on cancer survival is poorly understood. Within the VHM&PP cohort, 8,673 cancer patients (42.2% women) were followed over a median time of 11.9 years. Cox proportional hazard models were used to estimate the association of pre-diagnostic overweight (BMI 25.0-29.9 kg/m(2)) and obesity (BMI ≥ 30.0 kg/m(2)) with all-cause and cancer-specific mortality. Cubic restricted splines were additionally modeled. During 71,126 person-years, 4,571 deaths were observed. Compared to normal weight, overweight was associated with statistically significantly decreased all-cause mortality (HR 0.93; 95% CI 0.87-0.997) and cancer-specific mortality (HR 0.91; 95% CI 0.84-0.99). Underweight was statistically significantly associated with 28% increased overall mortality, in particular in men [HR 2.02 (95% CI 1.43-2.83) vs. HR 0.96 (95% CI 0.71-1.30) in women]. J-shaped associations were found between BMI and mortality with the nadir around a BMI of 25 kg/m(2). Analysis by cancer site showed though not statistically significantly that overweight was associated with reduced mortality, while obesity was associated with increased cancer-specific mortality except cancers of the upper...Continue Reading

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Citations

Aug 1, 2016·Current Oncology Reports·Hannah LennonAndrew G Renehan
Sep 2, 2016·The American Journal of Clinical Nutrition·Viola WalterHermann Brenner
Jan 27, 2021·Critical Reviews in Oncology/hematology·Vita JaspanVioleta Popov
Feb 9, 2021·Frontiers in Oncology·Ishrat RahmanMozaffarul Islam

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