Associations of Prenatal and Perinatal Factors with Cortisol Diurnal Pattern and Reactivity to Stress at Preschool Age Among Children Living in Poverty

Journal of Clinical Research in Pediatric Endocrinology
Maha E ElhassanJulie C Lumeng

Abstract

To examine the association of pre- and perinatal factors with diurnal cortisol pattern and reactivity to a stressor at preschool age among children living in poverty. Preschool aged children (n=275) provided saliva samples 3 times per day for 3 days to assess circadian rhythmicity (intercept and slope reflected diurnal pattern) and during a behavioral stress elicitation protocol to measure reactivity (5 samples before, during and after the stressor). Pre- and perinatal predictors were pregnancy weight gain, pre-pregnancy body mass index (BMI), infant birth weight z-score and gestational age. We ran 7 linear regression models predicting each of the cortisol outcomes including all pre- and perinatal predictors and covariates simultaneously. Greater pregnancy weight gain predicted higher morning cortisol [b=0.020 (SE 0.007), p=0.003]. Greater pregnancy weight gain also predicted higher cortisol at recovery from the stressor in girls only [β=0.002 (SE 0.001), p=0.036]. There was no association of pre-pregnancy BMI with any cortisol outcome. Higher birth weight z-score predicted higher morning cortisol in the total sample [β=0.134 (SE 0.066, p=0.043]. Greater gestational age predicted lower cortisol during peak stress in the sample ...Continue Reading

Citations

Feb 22, 2017·Developmental Psychobiology·Jenna C ThomasUNKNOWN APrON Study Team
Dec 21, 2018·Journal of Medical Primatology·Cun LiPeter W Nathanielsz
Feb 13, 2019·PeerJ·Sachiko IwataOsuke Iwata
Jul 30, 2021·Neuroscience and Biobehavioral Reviews·Minerva Ortiz-ValladaresNorma Angélica Moy-López

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Methods Mentioned

BETA
saliva collection

Software Mentioned

SAS

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