Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy.

The Pediatric Infectious Disease Journal
Joseph CerviaPACTG 1010 Team

Abstract

To measure proinflammatory cytokines (PIC) in HIV-infected children beginning or changing antiretroviral therapy (ART), evaluating associations with virologic, immunologic, serum lipid, growth, and body composition measures, markers of growth hormone action and glucose metabolism. Forty-nine prepubertal HIV-infected children had measurements of viral load (VL), CD4 lymphocyte count and percentage, serum lipids, apolipoprotein AI/B, IGF-1, IGFBP-1, and IGFBP-3, anthropometry, bioelectrical impedance analysis, TNF-α, IL-1 β, and IL-6 at baseline and 48 weeks of ART. Baseline levels were detectable (>0.1 pg/mL) for IL-1 β in 28 of 48, and for TNF-α and Il-6 in all 49 children. TNF-α decreased with ART (P < 0.001) and IL-6 demonstrated a similar trend (P = 0.065). Children with 48-week VL <400 copies/mL had greater declines in TNF-α (mean 45%) than subjects with higher VL (5%; P = 0.009). Each 10% improvement in CD4% was associated with 26% lower TNF-α (P = 0.002) and 31% lower IL-6 (P = 0.016). Greater reductions in TNF-α were associated with lower total/HDL cholesterol ratio (P = 0.003) at week 48. In HIV-infected children initiating or changing ART, PIC were detectable at baseline and decreased over 48 weeks. Better immunologic ...Continue Reading

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Citations

May 12, 2011·Journal of Tropical Pediatrics·Amandine CournilPhilippe Msellati
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Lindsey A Loomba-AlbrechtCaroline J Chantry
Jun 24, 2011·Journal of Pharmaceutical Sciences·Latoya GriffinKim L R Brouwer
Apr 12, 2015·Médecine et maladies infectieuses·J Jesson, V Leroy
Sep 15, 2017·Journal of the Pediatric Infectious Diseases Society·Ann J MelvinUNKNOWN PENPACT-1 (PENTA 9/PACTG 390/ANRS 103) Study Team
Oct 18, 2016·The Pediatric Infectious Disease Journal·Ann J MelvinUNKNOWN P1063 Study Team
Dec 1, 2017·The Pediatric Infectious Disease Journal·C PadmapriyadarsiniSoumya Swaminathan
Dec 6, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shirin HeidariElly Katabira
Apr 7, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinyu ZhangZhi Q Yao
Aug 25, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica S FlanneryMatthew T Sutherland

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