Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents

BioMed Research International
Nasser M Al-DaghriMajed S Alokail

Abstract

Nitric oxide (NOx) is an important biomolecule which interacts with other molecules including 25(OH)D to mediate various metabolic pathways. Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in apparently healthy adolescents have never been studied. A total of 740 (245 boys and 495 girls) apparently healthy Saudi adolescents aged 10-17 years were included in this cross-sectional study, to determine the associations of NOx with 25(OH)D and other biomarkers in Saudi adolescents. Serum NOx, 25(OH)D, and other biochemical and anthropometric parameters were measured following standard protocols and manufacturers' guidelines. NOx level was significantly higher in boys than girls (p<0.001). In all subjects, NOx showed a significant inverse correlation with 25(OH)D. After stratification according to sex however this significant association was observed only in boys and not in girls. NOx was also significantly associated with BMI, serum triglycerides, and systolic blood pressure in all subjects. The significantly inverse association of NOx and 25(OH)D among apparently healthy adolescents is influenced by sex and further strengthens the extraskeletal role of 25(OH)D in ma...Continue Reading

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·K Pantopoulos, M W Hentze
Jan 1, 1994·Life Sciences·B BrüneE G Lapetina
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·B V KhanR M Medford
Jun 11, 1998·Human Reproduction Update·M RosselliR K Dubey
Jan 28, 2003·Blood Cells, Molecules & Diseases·Xiao-bing LiuDavid J Haile
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Cornelius F H MuellerDavid G Harrison
Sep 5, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dimitrios Tsikas
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Mayi Mayret-MesquitiNoé Alvarado-Vasquez
Oct 1, 2008·Osteoarthritis and Cartilage·Steven B Abramson
Sep 8, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joern R SteinertIan D Forsythe
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Claudio MolinariCarlo Cisari
Sep 6, 2011·European Heart Journal·Ulrich Förstermann, William C Sessa
Jan 18, 2014·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Faisal BaraasDede Kusmana
Feb 28, 2014·European Journal of Clinical Investigation·Antonio J López-FarréCarlos Macaya
Mar 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W CheckleyUNKNOWN PURA Study Investigators
Jul 10, 2014·International Journal of Immunopathology and Pharmacology·H A Malek, A Shata
Dec 3, 2015·The Journal of Steroid Biochemistry and Molecular Biology·K van der MeijdenN Bravenboer
Jun 24, 2017·BMC Public Health·Daniel SowahSebastian Straube

❮ Previous
Next ❯

Citations

Aug 23, 2019·The Journal of International Medical Research·Meng-Lei HaoDong-Lai Wang
Jan 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zeinab GhorbaniMaryam Mahmoudi
Jun 1, 2021·Frontiers in Neurology·Valentina RebecchiMaurizio Versino

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo
Josiane Aparecida de MirandaCarla Márcia Moreira Lanna
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Marie-Hélène Gannagé-YaredGeorges Halaby
© 2022 Meta ULC. All rights reserved