Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study.

Neurotoxicity Research
He-Ying HuJin-Tai Yu

Abstract

As brain insults, sleep disorders could enhance microglial activation and aggravate neuroinflammation. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) serves as a readout for TREM2-associated microglial responses. We aimed to study the association of sleep characteristics with CSF sTREM2 in cognitively normal (CN) older adults. Linear and non-linear regression analyses were conducted in 830 participants with measurements of sleep characteristics and CSF sTREM2, after adjusting for age, sex, education, the Chinese-Modified Mini-Mental State Examination (CM-MMSE) scores, and APOE4 status. These analyses were also performed in amyloid-negative (A -) and amyloid-positive (A +) individuals. Linear relationships between sleep characteristics and CSF sTREM2 were found. In all the participants, sleep efficiency score in Pittsburgh Sleep Quality Index (PSQI) (p = 0.037) showed a positive linear association with CSF sTREM2. In A + individuals, the grade of PSQI total score (p = 0.011) as well as subjective sleep quality score (p = 0.048) and sleep efficiency score (p < 0.001) in PSQI were positively associated with CSF sTREM2. Besides, several U-shaped relationships were revealed of sleep-ti...Continue Reading

References

Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanRichard J Caselli
May 18, 2010·Neurobiology of Aging·Christopher C RoweVictor L Villemagne
Feb 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carla S Möller-LevetDerk-Jan Dijk
Sep 14, 2013·Current Biology : CB·Ted AbelMatthew P Walker
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Jun 5, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yi ZengJames W Vaupel
Jul 6, 2014·Science Translational Medicine·Gernot KleinbergerChristian Haass
Jan 30, 2015·Nature Communications·Carlo CondelloJaime Grutzendler
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
Jun 11, 2015·Neurobiology of Aging·Kate E SprecherRuth M Benca
Apr 12, 2016·JAMA Neurology·Anja SoldanUNKNOWN BIOCARD Research Team
Apr 20, 2016·Sleep·Belinda M BrownUNKNOWN AIBL Research Group
Apr 20, 2016·The Journal of Experimental Medicine·Yaming WangMarco Colonna
Dec 21, 2016·Journal of the American Geriatrics Society·Ke-Liang ChenQi-Hao Guo
Apr 23, 2017·Journal of Molecular Biology·Daniel L Kober, Tom J Brett
May 26, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michele BellesiChiara Cirelli
Jan 13, 2018·The Journal of Experimental Medicine·Wilbur M SongMarco Colonna
Aug 22, 2018·Frontiers in Cellular Neuroscience·Hiroyuki Konishi, Hiroshi Kiyama
Jan 9, 2019·Nature Neuroscience·Samira ParhizkarChristian Haass
Dec 28, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Wei XuLan Tan
Jan 12, 2020·Immunity·Charlotte MadoreOleg Butovsky
Apr 12, 2020·Molecular Neurodegeneration·Ling-Zhi MaJin-Tai Yu

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GraphPad Prism
MoCA
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