Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome

Reproductive Biology and Endocrinology : RB&E
Basmah Al OmraniHamad Al Sufyan

Abstract

Male factor infertility is quite common as 30-50% of infertility cases are due to sperm defects. The high sperm DNA fragmentation is one of the causes of male factor infertility. Many factors cause sperm DNA fragmentation and could be testicular or post-testicular. The purpose of this study was to assess relationships among sperm DNA fragmentation, lifestyle factors and semen values of Saudi men and to determine impact of sperm DNA fragmentation on ICSI cycle outcome. The duration of this study was from January 2015 to June 2016. The cases with female factor infertility were excluded. In total 94 couples were selected for investigation. The study parameters were male age, body mass index, smoking, semen values, % sperm DNA fragmentation, fertilization rate and pregnancy outcome. The ICSI procedure was performed in all patients per standard protocol. The semen samples were grouped based on % sperm DNA fragmentation into < 15%, 15-30 and > 30% which corresponded to low, moderate and high sperm DNA fragmentation, respectively. There was no difference in ICSI outcome in low and moderate sperm DNA fragmentation, however, in high sperm DNA fragmentation no patient achieved pregnancy. In this study, 53.19% Saudi men had low, 32.98% mo...Continue Reading

References

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Citations

Jun 15, 2019·International Journal of Environmental Research and Public Health·Kamil GillMałgorzata Piasecka
Nov 28, 2019·Andrologia·Fayez A AlmabhouhHarbindar Jeet Singh
May 20, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kamil GillMalgorzata Piasecka
Sep 6, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Shinnosuke Kuroda
Nov 23, 2019·Journal of Assisted Reproduction and Genetics·Katherine A GreenJason M Franasiak
Apr 10, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Anupama Deenadayal MettlerTara Mahendran
Feb 28, 2020·BioMed Research International·Hua NieWeibing Qin
Jul 25, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Albert Salas-HuetosJordi Salas-Salvadó
Aug 11, 2020·The World Journal of Men's Health·Ashok AgarwalRupin Shah
Mar 2, 2021·Clinical and Experimental Reproductive Medicine·Alaa El Din-Abdel Aal MoubasherHisham Diab Gaber
Jul 3, 2021·International Journal of Environmental Research and Public Health·Kamil GillMalgorzata Piasecka

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Methods Mentioned

BETA
Assay

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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