Associations of status and change measures of neuropsychological function with pathologic changes in elderly, originally nondemented subjects

Archives of Neurology
H CrystalR B Lipton

Abstract

To describe the association between status and change of neuropsychological function and postmortem neuropathologic findings in subjects with Alzheimer's disease, vascular dementia, normal aging, and pathologic aging. Volunteer cohort study. Volunteers were interviewed and tested in outpatient-clinical research offices. Nondemented, healthy, community-residing subjects, initially between 75 and 85 years of age, who participated in the Bronx Aging Study and had at least 2 years of neuropsychological data and quantitative neuropathologic examinations. Initial summary neuropsychological score, rate of change score. Summary neuropsychological scores at baseline in subjects who subsequently developed pathologically confirmed Alzheimer's disease or vascular dementia were 0.8 z units lower than those of subjects classified in the normal or pathologic aging subgroups (P < .05). Subjects with Alzheimer's disease showed more neuropsychological change over time than subjects in the normal or pathologic aging groups (P < .001). Normal subjects and subjects with pathologic aging did not differ in baseline scores or rate of change. Level of education was strongly associated with initial neuropsychological scores (P < .004), but not with chan...Continue Reading

Citations

Aug 21, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·L M WaiteH Creasey
Jul 17, 2009·The New England Journal of Medicine·Richard J CaselliEric M Reiman
Jul 23, 1999·Experimental Neurology·E J MufsonJ H Kordower
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T W MitchellS E Arnold
May 7, 2002·The Australian and New Zealand Journal of Psychiatry·J N Trollor, M J Valenzuela
Sep 1, 1996·Neurobiology of Aging·D W DicksonH Vlassara

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