Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly

Biogerontology
Giovanni RavagliaFederico Licastro

Abstract

Serum interleukin-6 (sIL6) is an acknowledged predictor of all-cause mortality in older age. A common G/C polymorphism has been identified at position -174 of the IL6 gene promoter (IL6-174G>C), but its associations with sIL6 and mortality are still unclear. Data from a population-based elderly cohort (n=824) were used to study the associations of baseline sIL6 with the IL6-174 C-allele (C+) carrier status and all-cause mortality at 4 years, in the presence and absence of preexisting major diseases (PMD). Analyses were adjusted for socio-demographic factors and body-mass-index. Three-hundred-eighty-eight participants (47.1%) had PMD. Compared to the bottom sIL6 quartile, mortality increased both in presence [Hazard Ratio (HR)=3.04; 95% confidence interval (CI): 1.48-6.25] and absence of PMD [HR=3.91; 95%CI: 1.42-10.72] for the third higher sIL6 quartile, but only in presence of PMD for the top sIL6 quartile [HR=2.30; 95%CI: 1.09-4.83]. In absence of PMD, C+ carrier status did not affect both sIL6 and mortality. In presence of PMD, C+ carrier status was associated with increased baseline sIL6 [odds ratio 2.01; 95%CI: 1.25-3.22, for all sIL6 quartiles above the bottom] but not with increased mortality risk. A survival advantage w...Continue Reading

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Citations

Oct 16, 2007·BMC Medical Genetics·Emelia J BenjaminRamachandran S Vasan
Dec 7, 2013·Aging Clinical and Experimental Research·Phuong-Nhi BoriesElena Paillaud
Jul 12, 2012·The Prostate·Elizabeth A TindallUNKNOWN Australian Prostate Cancer BioResource
Apr 24, 2013·Asian Pacific Journal of Tropical Medicine·Lin-Zhong CuiJie Zhou
Nov 10, 2013·PloS One·Francesca TotaroMario Capasso
Apr 11, 2013·Psychoneuroendocrinology·Marc UdinaRocío Martín-Santos
Jan 1, 2010·Cancers·Elizabeth A TindallDesiree C Petersen
Mar 22, 2008·Clinical Chemistry·Andrew J P SmithSteve E Humphries
Oct 14, 2020·International Journal of Colorectal Disease·Beatriz Piantoni GonçalvesAndréa Name Colado Simão

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