Associations of TNF-A-1031TT and -857TT genotypes with Helicobacter pylori seropositivity and gastric atrophy among Japanese Brazilians.

International Journal of Clinical Oncology
Yoshiko AtsutaNobuyuki Hamajima

Abstract

Our previous study in a Japanese population showed elevated Helicobacter pylori seropositivity in those with tumor necrosis factor (TNF) A -1031TT and -857TT genotypes. This study examined the associations of this seropositivity and serum pepsinogen (PG) levels with these genotypes in Japanese Brazilians. The subjects were 963 individuals (399 males and 564 females), aged 33 to 69 years, from four regions (Sao Paulo, Curitiba, Mogi das Cruzes, and Mirandopolis) in Brazil. Gastric atrophy was evaluated with serum pepsinogens (PGI < 70 ng/dl and PGI/II < 3), and TNF T-1031C and C-857T were genotyped by polymerase chain reaction with confronting two-pair primers (PCR-CTPP). The frequency of TNF-A T-1031C was 68.4% TT, 28.4% TC, and 3.3% CC, and that of C-857T was 64.5% CC, 31.7% CT, and 3.8% TT, whose distributions were in Hardy-Weinberg equilibrium. No significant associations of the genotypes with H. pylori seropositivity or gastric atrophy were found. However, male participants with TNF-A -1031CC and -857CC showed the lowest seropositivity (43.8% out of 16), and males with TNF-A -1031TT and -857TT showed the highest (61.5% out of 13). This study demonstrated that the associations between H. pylori seropositivity and TNF-A genot...Continue Reading

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Citations

Oct 7, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Lakhdar GhazouaniTouhami Mahjoub
Mar 8, 2011·Yi chuan = Hereditas·Cai-Yun He, Yuan Yuan
Jan 20, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sayo KawaiNobuyuki Hamajima
Jul 13, 2007·European Journal of Gastroenterology & Hepatology·Stephan Hellmig
May 1, 2010·Personalized Medicine·Nobuyuki Hamajima, Asahi Hishida

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