Associations of Whole and Refined Grain Intakes with Adiposity-Related Cancer Risk in the Framingham Offspring Cohort (1991-2013)

Nutrition and Cancer
Nour MakaremNiyati Parekh

Abstract

Case-control studies suggest that higher whole grain and lower refined grain intakes are associated with reduced cancer risk, but longitudinal evidence is limited. The objective of this prospective cohort study is to evaluate associations between whole and refined grains and their food sources in relation to adiposity-related cancer risk. Participants were adults from the Framingham Offspring cohort (N = 3,184; ≥18 yr). Diet, measured using a food frequency questionnaire, medical and lifestyle data were collected at exam 5 (1991-95). Between 1991 and 2013, 565 adiposity-related cancers were ascertained using pathology reports. Cox proportional hazards models were used to estimate adjusted hazard ratios and 95% confidence intervals for associations of whole and refined grains with risk of adiposity-related cancers combined and with risk of breast and prostate cancers in exploratory site-specific analyses. Null associations between whole and refined grains and combined incidence of adiposity-related cancers were observed in multivariable-adjusted models (HR: 0.94; 95% CI: 0.71-1.23 and HR: 0.98; 95% CI: 0.70-1.38, respectively). In exploratory analyses, higher intakes of whole grains (oz eq/day) and whole grain food sources (serv...Continue Reading

References

Dec 1, 1975·Preventive Medicine·M FeinleibW P Castelli
Jan 1, 1995·Nutrition and Cancer·D R JacobsL Marquart
May 20, 1998·Nutrition and Cancer·D R JacobsL H Kushi
Aug 11, 1998·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C P CaygillM J Hill
Feb 16, 1999·The American Journal of Clinical Nutrition·F B HuW C Willett
Jun 30, 2000·Journal of the American College of Nutrition·J L Slavin
Jan 5, 2002·Nutrition and Cancer·C M KasumUNKNOWN Iowa Women's Health Study
Jan 26, 2002·Cancer Causes & Control : CCC·K K NicodemusA R Folsom
Jan 31, 2004·Cancer Causes & Control : CCC·Marjorie L McCulloughMichael J Thun
Dec 4, 2004·Cancer Causes & Control : CCC·Kana WuEdward Giovannucci
Aug 2, 2005·Journal of Nutrition Education and Behavior·Brian Wansink, Junyong Kim
Mar 27, 2007·The British Journal of Nutrition·Christopher W ThaneSusan A Jebb
May 11, 2007·The American Journal of Clinical Nutrition·Arthur SchatzkinFrances E Thompson
May 10, 2008·Archives of Physiology and Biochemistry·Andrew G RenehanCaroline Dive
Jun 1, 2004·Nutrition Research Reviews·Joanne Slavin
Sep 4, 2009·The Journal of Nutrition·Nicola M McKeownEdward Saltzman
Oct 15, 2009·Annual Review of Medicine·Darren L RobertsAndrew G Renehan
Oct 16, 2009·Journal of the American College of Nutrition·Nicola M McKeownPaul F Jacques
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin
Nov 26, 2010·The American Journal of Clinical Nutrition·Teresa T FungEdward Giovannucci
Dec 2, 2010·British Journal of Cancer·T J Key
Jan 12, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D AuneT Norat
Oct 17, 2012·Cancer Science·Kentaro ShikataYutaka Kiyohara
Mar 27, 2015·The American Journal of Clinical Nutrition·Alastair B RossNicola M McKeown
Jun 21, 2015·European Journal of Epidemiology·Guri SkeieEiliv Lund
Aug 12, 2016·Breast Cancer Research and Treatment·Maryam S FarvidWalter C Willett
Aug 2, 2017·Vaccine· World Health Organization

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Citations

Nov 5, 2019·Advances in Nutrition·Julie Miller JonesHans J Braun
Aug 12, 2020·The American Journal of Clinical Nutrition·Evan Y W YuMaurice P Zeegers
Jan 9, 2021·Breast Cancer : Basic and Clinical Research·Liliana Silva-IguaAngela María Ruiz-Sternberg

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